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Preparation and characterization of branched polymers as postoperative anti-adhesion barriers

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Title: Preparation and characterization of branched polymers as postoperative anti-adhesion barriers
Authors: Way, Tzong-Der1, Hsieh, Shih-Rong2, Chang, Chi-Jung3 changcj@fcu.edu.tw, Hung, Tsung-Wei3, Chiu, Chun-Hwei4
Source: Applied Surface Science. Mar2010, Vol. 256 Issue 10, p3330-3336. 7p.
Subjects: Copolymers, Thin films, Adhesion, Organic synthesis, Biocompatibility, Polyethylene glycol, Lactones, Contact angle
Abstract: Abstract: Homopolymers and copolymers synthesized from biocompatible monomers with polyethylene glycol (PEG) and polycaprolactone side chains, were applied to separate healing tissues and prevent postsurgical adhesions. The results of the contact angle and the ESCA spectra reveal the presence of more PEG segments on the surface of the PEMC1 film than the P(EM)3(EMC4)1 film. The effects of the molecular structures on the surface properties, including the wetting properties and the anti-tissue adhesion behaviors, of the films were examined. Fluorescent polymer was fixed on the surface of the film to form the marking dot. The in vivo degradation behaviors of the surface-marked films were investigated non-invasively by monitoring the location of the fluorescent signal. The degradation behaviors of various films observed in the animal study were consistent with those observed by in vivo imaging. Proper arrangement of PEG segments on the polymer side chain helped to keep a large proportion of PEG segments close to the surface of the film. Such an arrangement represents an effective means of preventing postoperative tissue adhesion. [Copyright &y& Elsevier]
Copyright of Applied Surface Science is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 48467386
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Preparation and characterization of branched polymers as postoperative anti-adhesion barriers
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  Data: <searchLink fieldCode="AR" term="%22Way%2C+Tzong-Der%22">Way, Tzong-Der</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hsieh%2C+Shih-Rong%22">Hsieh, Shih-Rong</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Chang%2C+Chi-Jung%22">Chang, Chi-Jung</searchLink><relatesTo>3</relatesTo><i> changcj@fcu.edu.tw</i><br /><searchLink fieldCode="AR" term="%22Hung%2C+Tsung-Wei%22">Hung, Tsung-Wei</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Chiu%2C+Chun-Hwei%22">Chiu, Chun-Hwei</searchLink><relatesTo>4</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Applied+Surface+Science%22">Applied Surface Science</searchLink>. Mar2010, Vol. 256 Issue 10, p3330-3336. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Copolymers%22">Copolymers</searchLink><br /><searchLink fieldCode="DE" term="%22Thin+films%22">Thin films</searchLink><br /><searchLink fieldCode="DE" term="%22Adhesion%22">Adhesion</searchLink><br /><searchLink fieldCode="DE" term="%22Organic+synthesis%22">Organic synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Polyethylene+glycol%22">Polyethylene glycol</searchLink><br /><searchLink fieldCode="DE" term="%22Lactones%22">Lactones</searchLink><br /><searchLink fieldCode="DE" term="%22Contact+angle%22">Contact angle</searchLink>
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  Label: Abstract
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  Data: Abstract: Homopolymers and copolymers synthesized from biocompatible monomers with polyethylene glycol (PEG) and polycaprolactone side chains, were applied to separate healing tissues and prevent postsurgical adhesions. The results of the contact angle and the ESCA spectra reveal the presence of more PEG segments on the surface of the PEMC1 film than the P(EM)3(EMC4)1 film. The effects of the molecular structures on the surface properties, including the wetting properties and the anti-tissue adhesion behaviors, of the films were examined. Fluorescent polymer was fixed on the surface of the film to form the marking dot. The in vivo degradation behaviors of the surface-marked films were investigated non-invasively by monitoring the location of the fluorescent signal. The degradation behaviors of various films observed in the animal study were consistent with those observed by in vivo imaging. Proper arrangement of PEG segments on the polymer side chain helped to keep a large proportion of PEG segments close to the surface of the film. Such an arrangement represents an effective means of preventing postoperative tissue adhesion. [Copyright &y& Elsevier]
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  Data: <i>Copyright of Applied Surface Science is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.apsusc.2009.12.029
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      – Code: eng
        Text: English
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        PageCount: 7
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        Type: general
      – SubjectFull: Thin films
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      – SubjectFull: Adhesion
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      – SubjectFull: Polyethylene glycol
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      – SubjectFull: Lactones
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      – SubjectFull: Contact angle
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      – TitleFull: Preparation and characterization of branched polymers as postoperative anti-adhesion barriers
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            NameFull: Way, Tzong-Der
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            NameFull: Hsieh, Shih-Rong
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            NameFull: Chang, Chi-Jung
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              Text: Mar2010
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              Y: 2010
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