View in EDS

Development and optimization of a doxorubicin loaded poly(lactic acid) contrast agent for ultrasound directed drug delivery

Saved in:
Bibliographic Details
Title: Development and optimization of a doxorubicin loaded poly(lactic acid) contrast agent for ultrasound directed drug delivery
Authors: Eisenbrey, J.R.1 jeisenbrey@gmail.com, Burstein, O. Mualem1 odelmb@gmail.com, Kambhampati, R.1 rekhakamb@gmail.com, Forsberg, F.2 flemming.forsberg@jefferson.edu, Liu, J.-B.2 ji-bin.liu@jefferson.edu, Wheatley, M.A.1 wheatley@coe.drexel.edu
Source: Journal of Controlled Release. Apr2010, Vol. 143 Issue 1, p38-44. 7p.
Subjects: Drug development, Mathematical optimization, Doxorubicin, Lactic acid, Intravenous therapy, Ultrasound contrast media, Drug delivery systems
Geographic Terms: New Zealand
Abstract: Abstract: An echogenic, intravenous drug delivery platform is proposed in which an encapsulated chemotherapeutic can travel to a desired location and drug delivery can be triggered using external, focused ultrasound at the area of interest. Three methods of loading poly(lactic acid) (PLA) shelled ultrasound contrast agents (UCA) with doxorubicin are presented. Effects on encapsulation efficiency, in vitro enhancement, stability, particle size, morphology and release during UCA rupture are compared by loading method and drug concentration. An agent containing doxorubicin within the shell was selected as an ideal candidate for future hepatocellular carcinoma studies. The agent achieved a maximal drug load of 6.2mg Dox/g PLA with an encapsulation efficiency of 20.5%, showed a smooth surface morphology and tight size distribution (poly dispersity index=0.309) with a peak size of 1865nm. Acoustically, the agent provided 19dB of enhancement in vitro at a dosage of 10µg/ml, with a half life of over 15min. In vivo, the agent provided ultrasound enhancement of 13.4±1.6dB within the ascending aorta of New Zealand rabbits at a dose of 0.15ml/kg. While the drug-incorporated agent is thought to be well suited for future drug delivery experiments, this study has shown that agent properties can be tailored for specific applications based on choice of drug loading method. [Copyright &y& Elsevier]
Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 48601988
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Development and optimization of a doxorubicin loaded poly(lactic acid) contrast agent for ultrasound directed drug delivery
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Eisenbrey%2C+J%2ER%2E%22">Eisenbrey, J.R.</searchLink><relatesTo>1</relatesTo><i> jeisenbrey@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Burstein%2C+O%2E+Mualem%22">Burstein, O. Mualem</searchLink><relatesTo>1</relatesTo><i> odelmb@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Kambhampati%2C+R%2E%22">Kambhampati, R.</searchLink><relatesTo>1</relatesTo><i> rekhakamb@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Forsberg%2C+F%2E%22">Forsberg, F.</searchLink><relatesTo>2</relatesTo><i> flemming.forsberg@jefferson.edu</i><br /><searchLink fieldCode="AR" term="%22Liu%2C+J%2E-B%2E%22">Liu, J.-B.</searchLink><relatesTo>2</relatesTo><i> ji-bin.liu@jefferson.edu</i><br /><searchLink fieldCode="AR" term="%22Wheatley%2C+M%2EA%2E%22">Wheatley, M.A.</searchLink><relatesTo>1</relatesTo><i> wheatley@coe.drexel.edu</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Controlled+Release%22">Journal of Controlled Release</searchLink>. Apr2010, Vol. 143 Issue 1, p38-44. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Drug+development%22">Drug development</searchLink><br /><searchLink fieldCode="DE" term="%22Mathematical+optimization%22">Mathematical optimization</searchLink><br /><searchLink fieldCode="DE" term="%22Doxorubicin%22">Doxorubicin</searchLink><br /><searchLink fieldCode="DE" term="%22Lactic+acid%22">Lactic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Intravenous+therapy%22">Intravenous therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Ultrasound+contrast+media%22">Ultrasound contrast media</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22New+Zealand%22">New Zealand</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Abstract: An echogenic, intravenous drug delivery platform is proposed in which an encapsulated chemotherapeutic can travel to a desired location and drug delivery can be triggered using external, focused ultrasound at the area of interest. Three methods of loading poly(lactic acid) (PLA) shelled ultrasound contrast agents (UCA) with doxorubicin are presented. Effects on encapsulation efficiency, in vitro enhancement, stability, particle size, morphology and release during UCA rupture are compared by loading method and drug concentration. An agent containing doxorubicin within the shell was selected as an ideal candidate for future hepatocellular carcinoma studies. The agent achieved a maximal drug load of 6.2mg Dox/g PLA with an encapsulation efficiency of 20.5%, showed a smooth surface morphology and tight size distribution (poly dispersity index=0.309) with a peak size of 1865nm. Acoustically, the agent provided 19dB of enhancement in vitro at a dosage of 10µg/ml, with a half life of over 15min. In vivo, the agent provided ultrasound enhancement of 13.4±1.6dB within the ascending aorta of New Zealand rabbits at a dose of 0.15ml/kg. While the drug-incorporated agent is thought to be well suited for future drug delivery experiments, this study has shown that agent properties can be tailored for specific applications based on choice of drug loading method. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=48601988
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.jconrel.2009.12.021
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 38
    Subjects:
      – SubjectFull: Drug development
        Type: general
      – SubjectFull: Mathematical optimization
        Type: general
      – SubjectFull: Doxorubicin
        Type: general
      – SubjectFull: Lactic acid
        Type: general
      – SubjectFull: Intravenous therapy
        Type: general
      – SubjectFull: Ultrasound contrast media
        Type: general
      – SubjectFull: Drug delivery systems
        Type: general
      – SubjectFull: New Zealand
        Type: general
    Titles:
      – TitleFull: Development and optimization of a doxorubicin loaded poly(lactic acid) contrast agent for ultrasound directed drug delivery
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Eisenbrey, J.R.
      – PersonEntity:
          Name:
            NameFull: Burstein, O. Mualem
      – PersonEntity:
          Name:
            NameFull: Kambhampati, R.
      – PersonEntity:
          Name:
            NameFull: Forsberg, F.
      – PersonEntity:
          Name:
            NameFull: Liu, J.-B.
      – PersonEntity:
          Name:
            NameFull: Wheatley, M.A.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 02
              M: 04
              Text: Apr2010
              Type: published
              Y: 2010
          Identifiers:
            – Type: issn-print
              Value: 01683659
          Numbering:
            – Type: volume
              Value: 143
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Journal of Controlled Release
              Type: main
ResultId 1