In vitro cellular adhesion and antimicrobial property of SiO2–MgO–Al2O3–K2O–B2O3–F glass ceramic.
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| Title: | In vitro cellular adhesion and antimicrobial property of SiO |
|---|---|
| Authors: | Kalmodia, Sushma1, Molla, Atiar Rahaman2, Basu, Bikramjit1 bikram@iitk.ac.in |
| Source: | Journal of Materials Science: Materials in Medicine. Apr2010, Vol. 21 Issue 4, p1297-1309. 13p. 5 Diagrams, 1 Chart, 4 Graphs. |
| Subjects: | Biomedical materials, Cell adhesion, Cell communication, Fibroblasts, Fluorine |
| Abstract: | The aim of the present study was to examine the cellular functionality and antimicrobial properties of SiO2–MgO–Al2O3–K2O–B2O3–F glass ceramics (GC) containing fluorophlogopite as major crystalline phase. The cellular morphology and cell adhesion study using human osteoblast-like Saos-2 cells and mouse fibroblast L929 cells reveals good in vitro cytocompatibility of GC. The potential use of the GC for biomedical application was also assessed by in vitro synthesis of the alkaline phosphatase (ALP) activity of Saos-2 cells. It is proposed that B2O3 actively enhances the cell adhesion and supports osteoconduction process, whereas, fluorine component significantly influences cell viability. The Saos-2 and L929 cells on GC shows extensive multidirectional network of actin cytoskeleton. The in vitro results of this study illustrate how small variation in fluorine and boron in base glass composition influences significantly the biocompatibility and antimicrobial bactericidal property, as evaluated using a range of biochemical assays. Importantly, it shows that the cell viability and osteoconduction can be promoted in glass ceramics with lower fluorine content. The underlying reasons for difference in biological properties are analyzed and reported. It is suggested that oriented crystalline morphology in the lowest fluorine containing glass ceramic enhanced cellular spreading. Overall, the in vitro cell adhesion, cell flattening, cytocompatibility and antimicrobial study of the three different compositions of glass ceramic clearly reveals that microstructure and base glass composition play an important role in enhancing the cellular functionality and antimicrobial property. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Materials Science: Materials in Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 48999299 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: In vitro cellular adhesion and antimicrobial property of SiO<subscript>2</subscript>–MgO–Al<subscript>2</subscript>O<subscript>3</subscript>–K<subscript>2</subscript>O–B<subscript>2</subscript>O<subscript>3</subscript>–F glass ceramic. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kalmodia%2C+Sushma%22">Kalmodia, Sushma</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Molla%2C+Atiar+Rahaman%22">Molla, Atiar Rahaman</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Basu%2C+Bikramjit%22">Basu, Bikramjit</searchLink><relatesTo>1</relatesTo><i> bikram@iitk.ac.in</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Materials+Science%3A+Materials+in+Medicine%22">Journal of Materials Science: Materials in Medicine</searchLink>. Apr2010, Vol. 21 Issue 4, p1297-1309. 13p. 5 Diagrams, 1 Chart, 4 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Biomedical+materials%22">Biomedical materials</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+adhesion%22">Cell adhesion</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+communication%22">Cell communication</searchLink><br /><searchLink fieldCode="DE" term="%22Fibroblasts%22">Fibroblasts</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorine%22">Fluorine</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The aim of the present study was to examine the cellular functionality and antimicrobial properties of SiO2–MgO–Al2O3–K2O–B2O3–F glass ceramics (GC) containing fluorophlogopite as major crystalline phase. The cellular morphology and cell adhesion study using human osteoblast-like Saos-2 cells and mouse fibroblast L929 cells reveals good in vitro cytocompatibility of GC. The potential use of the GC for biomedical application was also assessed by in vitro synthesis of the alkaline phosphatase (ALP) activity of Saos-2 cells. It is proposed that B2O3 actively enhances the cell adhesion and supports osteoconduction process, whereas, fluorine component significantly influences cell viability. The Saos-2 and L929 cells on GC shows extensive multidirectional network of actin cytoskeleton. The in vitro results of this study illustrate how small variation in fluorine and boron in base glass composition influences significantly the biocompatibility and antimicrobial bactericidal property, as evaluated using a range of biochemical assays. Importantly, it shows that the cell viability and osteoconduction can be promoted in glass ceramics with lower fluorine content. The underlying reasons for difference in biological properties are analyzed and reported. It is suggested that oriented crystalline morphology in the lowest fluorine containing glass ceramic enhanced cellular spreading. Overall, the in vitro cell adhesion, cell flattening, cytocompatibility and antimicrobial study of the three different compositions of glass ceramic clearly reveals that microstructure and base glass composition play an important role in enhancing the cellular functionality and antimicrobial property. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Materials Science: Materials in Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10856-009-3942-7 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 1297 Subjects: – SubjectFull: Biomedical materials Type: general – SubjectFull: Cell adhesion Type: general – SubjectFull: Cell communication Type: general – SubjectFull: Fibroblasts Type: general – SubjectFull: Fluorine Type: general Titles: – TitleFull: In vitro cellular adhesion and antimicrobial property of SiO2–MgO–Al2O3–K2O–B2O3–F glass ceramic. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kalmodia, Sushma – PersonEntity: Name: NameFull: Molla, Atiar Rahaman – PersonEntity: Name: NameFull: Basu, Bikramjit IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 09574530 Numbering: – Type: volume Value: 21 – Type: issue Value: 4 Titles: – TitleFull: Journal of Materials Science: Materials in Medicine Type: main |
| ResultId | 1 |
