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In vitro and in vivo degradation behaviors of thermosensitive poly(organophosphazene) hydrogels

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Title: In vitro and in vivo degradation behaviors of thermosensitive poly(organophosphazene) hydrogels
Authors: Park, Mi-Ran1,2, Cho, Chong-Su2,3, Song, Soo-Chang1 scsong@kist.re.kr
Source: Polymer Degradation & Stability. Jun2010, Vol. 95 Issue 6, p935-944. 10p.
Subjects: Polymer degradation, Polyphosphazenes, Polymer colloids, Biodegradation, Polymers, Organic synthesis, Polymer solutions, Temperature effect, Phase transitions
Abstract: Abstract: Biodegradable and thermosensitive poly(organophosphazenes) with various substituents were synthesized and their hydrolytic degradation properties were investigated in vitro and in vivo. The aqueous solutions of all polymers showed a sol–gel phase transition behavior depending on temperature changes. The side groups of polymers significantly affected the polymer degradation and accelerated hydrolysis of polymers in the order of carboxylic acid > depsipeptide > without carboxylic acid and depsipeptide. The increased gel strength led to the decreased hydrolysis rate. The polymer hydrogels with 750 Da of α-amino-ω-methoxy poly(ethylene glycol) were rapidly decreased by dissolution. The polymer degradation was also influenced by pH and temperature. The in vivo behaviors of mass decrease of the polymer hydrogels were similar with the in vitro results. These results suggest that the biodegradable and thermosensitive poly(organophosphazenes) hold great potentials as an injectable and biodegradable hydrogel for biomedical applications with controllable degradation rate. [Copyright &y& Elsevier]
Copyright of Polymer Degradation & Stability is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 50372305
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  Data: In vitro and in vivo degradation behaviors of thermosensitive poly(organophosphazene) hydrogels
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  Data: <searchLink fieldCode="AR" term="%22Park%2C+Mi-Ran%22">Park, Mi-Ran</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Cho%2C+Chong-Su%22">Cho, Chong-Su</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Song%2C+Soo-Chang%22">Song, Soo-Chang</searchLink><relatesTo>1</relatesTo><i> scsong@kist.re.kr</i>
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  Data: <searchLink fieldCode="JN" term="%22Polymer+Degradation+%26+Stability%22">Polymer Degradation & Stability</searchLink>. Jun2010, Vol. 95 Issue 6, p935-944. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Polymer+degradation%22">Polymer degradation</searchLink><br /><searchLink fieldCode="DE" term="%22Polyphosphazenes%22">Polyphosphazenes</searchLink><br /><searchLink fieldCode="DE" term="%22Polymer+colloids%22">Polymer colloids</searchLink><br /><searchLink fieldCode="DE" term="%22Biodegradation%22">Biodegradation</searchLink><br /><searchLink fieldCode="DE" term="%22Polymers%22">Polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Organic+synthesis%22">Organic synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Polymer+solutions%22">Polymer solutions</searchLink><br /><searchLink fieldCode="DE" term="%22Temperature+effect%22">Temperature effect</searchLink><br /><searchLink fieldCode="DE" term="%22Phase+transitions%22">Phase transitions</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Abstract: Biodegradable and thermosensitive poly(organophosphazenes) with various substituents were synthesized and their hydrolytic degradation properties were investigated in vitro and in vivo. The aqueous solutions of all polymers showed a sol–gel phase transition behavior depending on temperature changes. The side groups of polymers significantly affected the polymer degradation and accelerated hydrolysis of polymers in the order of carboxylic acid > depsipeptide > without carboxylic acid and depsipeptide. The increased gel strength led to the decreased hydrolysis rate. The polymer hydrogels with 750 Da of α-amino-ω-methoxy poly(ethylene glycol) were rapidly decreased by dissolution. The polymer degradation was also influenced by pH and temperature. The in vivo behaviors of mass decrease of the polymer hydrogels were similar with the in vitro results. These results suggest that the biodegradable and thermosensitive poly(organophosphazenes) hold great potentials as an injectable and biodegradable hydrogel for biomedical applications with controllable degradation rate. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Polymer Degradation & Stability is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.polymdegradstab.2010.03.024
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      – Code: eng
        Text: English
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        PageCount: 10
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        Type: general
      – SubjectFull: Polyphosphazenes
        Type: general
      – SubjectFull: Polymer colloids
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      – SubjectFull: Biodegradation
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      – SubjectFull: Polymers
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      – SubjectFull: Organic synthesis
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      – SubjectFull: Polymer solutions
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      – SubjectFull: Temperature effect
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      – SubjectFull: Phase transitions
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      – TitleFull: In vitro and in vivo degradation behaviors of thermosensitive poly(organophosphazene) hydrogels
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            NameFull: Park, Mi-Ran
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            NameFull: Cho, Chong-Su
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            NameFull: Song, Soo-Chang
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              Text: Jun2010
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              Y: 2010
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