Phantom-based experimental validation of computational fluid dynamics simulations on cerebral aneurysms.
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| Title: | Phantom-based experimental validation of computational fluid dynamics simulations on cerebral aneurysms. |
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| Authors: | Qi Sun1,2 qi.sun08@philips.com, Groth, Alexandra1, Bertram, Matthias1, Waechter, Irina1, Bruijns, Tom3, Hermans, Roel3, Aach, Til2 |
| Source: | Medical Physics. Sep2010, Vol. 37 Issue 9, p5054-5065. 12p. 1 Color Photograph, 1 Black and White Photograph, 1 Diagram, 4 Charts, 5 Graphs. |
| Subjects: | Imaging phantoms, Body composition models, Simulation methods & models, Intracranial aneurysms, Blood circulation |
| Abstract: | Purpose: Recently, image-based computational fluid dynamics (CFD) simulation has been applied to investigate the hemodynamics inside human cerebral aneurysms. The knowledge of the computed three-dimensional flow fields is used for clinical risk assessment and treatment decision making. However, the reliability of the application specific CFD results has not been thoroughly validated yet. Methods: In this work, by exploiting a phantom aneurysm model, the authors therefore aim to prove the reliability of the CFD results obtained from simulations with sufficiently accurate input boundary conditions. To confirm the correlation between the CFD results and the reality, virtual angiograms are generated by the simulation pipeline and are quantitatively compared to the experimentally acquired angiograms. In addition, a parametric study has been carried out to systematically investigate the influence of the input parameters associated with the current measuring techniques on the flow patterns. Results: Qualitative and quantitative evaluations demonstrate good agreement between the simulated and the real flow dynamics. Discrepancies of less than 15% are found for the relative root mean square errors of time intensity curve comparisons from each selected characteristic position. The investigated input parameters show different influences on the simulation results, indicating the desired accuracy in the measurements. Conclusions: This study provides a comprehensive validation method of CFD simulation for reproducing the real flow field in the cerebral aneurysm phantom under well controlled conditions. The reliability of the CFD is well confirmed. Through the parametric study, it is possible to assess the degree of validity of the associated CFD model based on the parameter values and their estimated accuracy range. [ABSTRACT FROM AUTHOR] |
| Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 53422107 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Phantom-based experimental validation of computational fluid dynamics simulations on cerebral aneurysms. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Qi+Sun%22">Qi Sun</searchLink><relatesTo>1,2</relatesTo><i> qi.sun08@philips.com</i><br /><searchLink fieldCode="AR" term="%22Groth%2C+Alexandra%22">Groth, Alexandra</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Bertram%2C+Matthias%22">Bertram, Matthias</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Waechter%2C+Irina%22">Waechter, Irina</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Bruijns%2C+Tom%22">Bruijns, Tom</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Hermans%2C+Roel%22">Hermans, Roel</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Aach%2C+Til%22">Aach, Til</searchLink><relatesTo>2</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Sep2010, Vol. 37 Issue 9, p5054-5065. 12p. 1 Color Photograph, 1 Black and White Photograph, 1 Diagram, 4 Charts, 5 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Imaging+phantoms%22">Imaging phantoms</searchLink><br /><searchLink fieldCode="DE" term="%22Body+composition+models%22">Body composition models</searchLink><br /><searchLink fieldCode="DE" term="%22Simulation+methods+%26+models%22">Simulation methods & models</searchLink><br /><searchLink fieldCode="DE" term="%22Intracranial+aneurysms%22">Intracranial aneurysms</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+circulation%22">Blood circulation</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: Recently, image-based computational fluid dynamics (CFD) simulation has been applied to investigate the hemodynamics inside human cerebral aneurysms. The knowledge of the computed three-dimensional flow fields is used for clinical risk assessment and treatment decision making. However, the reliability of the application specific CFD results has not been thoroughly validated yet. Methods: In this work, by exploiting a phantom aneurysm model, the authors therefore aim to prove the reliability of the CFD results obtained from simulations with sufficiently accurate input boundary conditions. To confirm the correlation between the CFD results and the reality, virtual angiograms are generated by the simulation pipeline and are quantitatively compared to the experimentally acquired angiograms. In addition, a parametric study has been carried out to systematically investigate the influence of the input parameters associated with the current measuring techniques on the flow patterns. Results: Qualitative and quantitative evaluations demonstrate good agreement between the simulated and the real flow dynamics. Discrepancies of less than 15% are found for the relative root mean square errors of time intensity curve comparisons from each selected characteristic position. The investigated input parameters show different influences on the simulation results, indicating the desired accuracy in the measurements. Conclusions: This study provides a comprehensive validation method of CFD simulation for reproducing the real flow field in the cerebral aneurysm phantom under well controlled conditions. The reliability of the CFD is well confirmed. Through the parametric study, it is possible to assess the degree of validity of the associated CFD model based on the parameter values and their estimated accuracy range. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1118/1.3483066 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 5054 Subjects: – SubjectFull: Imaging phantoms Type: general – SubjectFull: Body composition models Type: general – SubjectFull: Simulation methods & models Type: general – SubjectFull: Intracranial aneurysms Type: general – SubjectFull: Blood circulation Type: general Titles: – TitleFull: Phantom-based experimental validation of computational fluid dynamics simulations on cerebral aneurysms. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Qi Sun – PersonEntity: Name: NameFull: Groth, Alexandra – PersonEntity: Name: NameFull: Bertram, Matthias – PersonEntity: Name: NameFull: Waechter, Irina – PersonEntity: Name: NameFull: Bruijns, Tom – PersonEntity: Name: NameFull: Hermans, Roel – PersonEntity: Name: NameFull: Aach, Til IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 00942405 Numbering: – Type: volume Value: 37 – Type: issue Value: 9 Titles: – TitleFull: Medical Physics Type: main |
| ResultId | 1 |
