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A new rodent behavioral paradigm for studying forelimb movement

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Title: A new rodent behavioral paradigm for studying forelimb movement
Authors: Slutzky, Marc W.1,2,3 mslutzky@md.northwestern.edu, Jordan, Luke R.2, Bauman, Matthew J.2, Miller, Lee E.2,3,4
Source: Journal of Neuroscience Methods. Oct2010, Vol. 192 Issue 2, p228-232. 5p.
Subjects: Animal locomotion, Computer input-output equipment, Laboratory rats, Animal behavior, Neurobiology, Primates, Brain-computer interfaces
Abstract: Abstract: The center-out task is a standard paradigm often used to study the neural control of reaching movements in human and non-human primates. However, there are several disadvantages to the use of monkeys, notably costs, infrastructural requirements, and ethical considerations. Here we describe a similar task designed to examine forelimb movements in rats. Rats were trained to grasp a joystick with their forepaw and use it to control the movements of a sipper tube in two dimensions. The rats learned to move the joystick in four directions with at least 70% accuracy after about 45 days of training. In addition, rats were able to learn a reversed mapping between joystick and sipper tube movement. This is a more complicated behavior than has been previously demonstrated for rats, and it could allow more motor behavior studies to be conducted in rodents instead of monkeys. We currently are using this behavior to decode the rats’ forelimb movements from their brain signals. [Copyright &y& Elsevier]
Copyright of Journal of Neuroscience Methods is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 53789163
AccessLevel: 6
PubType: Academic Journal
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  Data: A new rodent behavioral paradigm for studying forelimb movement
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  Data: <searchLink fieldCode="DE" term="%22Animal+locomotion%22">Animal locomotion</searchLink><br /><searchLink fieldCode="DE" term="%22Computer+input-output+equipment%22">Computer input-output equipment</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+behavior%22">Animal behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Neurobiology%22">Neurobiology</searchLink><br /><searchLink fieldCode="DE" term="%22Primates%22">Primates</searchLink><br /><searchLink fieldCode="DE" term="%22Brain-computer+interfaces%22">Brain-computer interfaces</searchLink>
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  Data: Abstract: The center-out task is a standard paradigm often used to study the neural control of reaching movements in human and non-human primates. However, there are several disadvantages to the use of monkeys, notably costs, infrastructural requirements, and ethical considerations. Here we describe a similar task designed to examine forelimb movements in rats. Rats were trained to grasp a joystick with their forepaw and use it to control the movements of a sipper tube in two dimensions. The rats learned to move the joystick in four directions with at least 70% accuracy after about 45 days of training. In addition, rats were able to learn a reversed mapping between joystick and sipper tube movement. This is a more complicated behavior than has been previously demonstrated for rats, and it could allow more motor behavior studies to be conducted in rodents instead of monkeys. We currently are using this behavior to decode the rats’ forelimb movements from their brain signals. [Copyright &y& Elsevier]
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  Data: <i>Copyright of Journal of Neuroscience Methods is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=53789163
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        Value: 10.1016/j.jneumeth.2010.07.040
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      – SubjectFull: Laboratory rats
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              Text: Oct2010
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