A spatio-temporal model to describe the spread of Salmonella within a laying flock
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| Title: | A spatio-temporal model to describe the spread of Salmonella within a laying flock |
|---|---|
| Authors: | Zongo, Pascal1, Viet, Anne-France2,3, Magal, Pierre4, Beaumont, Catherine1 Catherine.Beaumont@tours.inra.fr |
| Source: | Journal of Theoretical Biology. Dec2010, Vol. 267 Issue 4, p595-604. 10p. |
| Subjects: | Spatio-temporal variation, Salmonella, Bacterial diseases, Communicable diseases, Poultry products, Food industry, Disease prevalence, Host-bacteria relationships |
| Abstract: | Abstract: Salmonella is one of the major sources of toxi-infection in humans, most often because of consumption of poultry products. The main reason for this association is the presence in hen flocks of silent carriers, i.e. animals harboring Salmonella without expressing any visible symptoms. Many prophylactic means have been developed to reduce the prevalence of Salmonella carrier-state. While none allows a total reduction of the risk, synergy could result in a drastic reduction of it. Evaluating the risk by modeling would be very useful to estimate such gain in food safety. Here, we propose an individual-based model which describes the spatio-temporal spread of Salmonella within a laying flock and takes into account the host response to bacterial infection. The model includes the individual bacterial load and the animals’ ability to reduce it thanks to the immune response, i.e. maximum bacterial dose that the animals may resist without long term carriage and, when carriers, length of bacterial clearance. For model validation, we simulated the Salmonella spread under published experimental conditions. There was a good agreement between simulated and observed published data. This model will thus allow studying the effects, on the spatiotemporal distribution of the bacteria, of both mean and variability of different elements of host response. [Copyright &y& Elsevier] |
| Copyright of Journal of Theoretical Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 55054657 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A spatio-temporal model to describe the spread of Salmonella within a laying flock – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Zongo%2C+Pascal%22">Zongo, Pascal</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Viet%2C+Anne-France%22">Viet, Anne-France</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Magal%2C+Pierre%22">Magal, Pierre</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Beaumont%2C+Catherine%22">Beaumont, Catherine</searchLink><relatesTo>1</relatesTo><i> Catherine.Beaumont@tours.inra.fr</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Theoretical+Biology%22">Journal of Theoretical Biology</searchLink>. Dec2010, Vol. 267 Issue 4, p595-604. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Spatio-temporal+variation%22">Spatio-temporal variation</searchLink><br /><searchLink fieldCode="DE" term="%22Salmonella%22">Salmonella</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial+diseases%22">Bacterial diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Communicable+diseases%22">Communicable diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Poultry+products%22">Poultry products</searchLink><br /><searchLink fieldCode="DE" term="%22Food+industry%22">Food industry</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+prevalence%22">Disease prevalence</searchLink><br /><searchLink fieldCode="DE" term="%22Host-bacteria+relationships%22">Host-bacteria relationships</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract: Salmonella is one of the major sources of toxi-infection in humans, most often because of consumption of poultry products. The main reason for this association is the presence in hen flocks of silent carriers, i.e. animals harboring Salmonella without expressing any visible symptoms. Many prophylactic means have been developed to reduce the prevalence of Salmonella carrier-state. While none allows a total reduction of the risk, synergy could result in a drastic reduction of it. Evaluating the risk by modeling would be very useful to estimate such gain in food safety. Here, we propose an individual-based model which describes the spatio-temporal spread of Salmonella within a laying flock and takes into account the host response to bacterial infection. The model includes the individual bacterial load and the animals’ ability to reduce it thanks to the immune response, i.e. maximum bacterial dose that the animals may resist without long term carriage and, when carriers, length of bacterial clearance. For model validation, we simulated the Salmonella spread under published experimental conditions. There was a good agreement between simulated and observed published data. This model will thus allow studying the effects, on the spatiotemporal distribution of the bacteria, of both mean and variability of different elements of host response. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Theoretical Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.jtbi.2010.09.030 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 595 Subjects: – SubjectFull: Spatio-temporal variation Type: general – SubjectFull: Salmonella Type: general – SubjectFull: Bacterial diseases Type: general – SubjectFull: Communicable diseases Type: general – SubjectFull: Poultry products Type: general – SubjectFull: Food industry Type: general – SubjectFull: Disease prevalence Type: general – SubjectFull: Host-bacteria relationships Type: general Titles: – TitleFull: A spatio-temporal model to describe the spread of Salmonella within a laying flock Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Zongo, Pascal – PersonEntity: Name: NameFull: Viet, Anne-France – PersonEntity: Name: NameFull: Magal, Pierre – PersonEntity: Name: NameFull: Beaumont, Catherine IsPartOfRelationships: – BibEntity: Dates: – D: 21 M: 12 Text: Dec2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 00225193 Numbering: – Type: volume Value: 267 – Type: issue Value: 4 Titles: – TitleFull: Journal of Theoretical Biology Type: main |
| ResultId | 1 |
