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Sustained delivery of human growth hormone using a polyelectrolyte complex-loaded thermosensitive polyphosphazene hydrogel

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Title: Sustained delivery of human growth hormone using a polyelectrolyte complex-loaded thermosensitive polyphosphazene hydrogel
Authors: Park, Mi-Ran1,2, Chun, ChangJu1, Ahn, Sung-Won3, Ki, Min-Hyo3, Cho, Chong-Su2,4, Song, Soo-Chang1 scsong@kist.re.kr
Source: Journal of Controlled Release. Nov2010, Vol. 147 Issue 3, p359-367. 9p.
Subjects: Controlled release drugs, Human growth hormone, Polyelectrolytes, Polyphosphazenes, Polymer solutions, Patient compliance, Pharmacokinetics, Polymer colloids
Abstract: Abstract: A combined system of polyelectrolyte complex (PEC) and injectable, biodegradable and thermosensitive poly(organophosphazene) hydrogel has been suggested as an injectable depot for a controlled and sustained delivery of human growth hormone (hGH) to improve patient compliance. PEC was prepared by mixing polycations with hGH to suppress diffusion of hGH from the hydrogel through an enlargement of the hydrodynamic size of hGH. Among the polycations, poly-l-arginine (PLA) formed a large complex with hGH and its size increased as the amount of PLA increased. When PLA and/or zinc were added to hGH, the time-dependent stability of hGH increased more than that of native-hGH. The polymer solution containing PECs formed a gel at 37°C. PLA decreased the initial release rate of hGH in proportion to the amount of PLA in vitro and in vivo. Zinc increased the released amount of hGH from the PEC-loaded hydrogel in vitro and in vivo. In a pharmacokinetic study in rats, a single administration of PEC-loaded hydrogel resulted in the sustained release of hGH for 5days. These results suggest that injectable, biodegradable, and thermosensitive PEC-loaded poly(organophosphazene) hydrogel has great potential to be used as an effective delivery system for a sustained release of hGH with improved patient compliance. [Copyright &y& Elsevier]
Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 55056286
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Sustained delivery of human growth hormone using a polyelectrolyte complex-loaded thermosensitive polyphosphazene hydrogel
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  Data: <searchLink fieldCode="AR" term="%22Park%2C+Mi-Ran%22">Park, Mi-Ran</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Chun%2C+ChangJu%22">Chun, ChangJu</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ahn%2C+Sung-Won%22">Ahn, Sung-Won</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Ki%2C+Min-Hyo%22">Ki, Min-Hyo</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Cho%2C+Chong-Su%22">Cho, Chong-Su</searchLink><relatesTo>2,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Song%2C+Soo-Chang%22">Song, Soo-Chang</searchLink><relatesTo>1</relatesTo><i> scsong@kist.re.kr</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Controlled+Release%22">Journal of Controlled Release</searchLink>. Nov2010, Vol. 147 Issue 3, p359-367. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Controlled+release+drugs%22">Controlled release drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Human+growth+hormone%22">Human growth hormone</searchLink><br /><searchLink fieldCode="DE" term="%22Polyelectrolytes%22">Polyelectrolytes</searchLink><br /><searchLink fieldCode="DE" term="%22Polyphosphazenes%22">Polyphosphazenes</searchLink><br /><searchLink fieldCode="DE" term="%22Polymer+solutions%22">Polymer solutions</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+compliance%22">Patient compliance</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacokinetics%22">Pharmacokinetics</searchLink><br /><searchLink fieldCode="DE" term="%22Polymer+colloids%22">Polymer colloids</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Abstract: A combined system of polyelectrolyte complex (PEC) and injectable, biodegradable and thermosensitive poly(organophosphazene) hydrogel has been suggested as an injectable depot for a controlled and sustained delivery of human growth hormone (hGH) to improve patient compliance. PEC was prepared by mixing polycations with hGH to suppress diffusion of hGH from the hydrogel through an enlargement of the hydrodynamic size of hGH. Among the polycations, poly-l-arginine (PLA) formed a large complex with hGH and its size increased as the amount of PLA increased. When PLA and/or zinc were added to hGH, the time-dependent stability of hGH increased more than that of native-hGH. The polymer solution containing PECs formed a gel at 37°C. PLA decreased the initial release rate of hGH in proportion to the amount of PLA in vitro and in vivo. Zinc increased the released amount of hGH from the PEC-loaded hydrogel in vitro and in vivo. In a pharmacokinetic study in rats, a single administration of PEC-loaded hydrogel resulted in the sustained release of hGH for 5days. These results suggest that injectable, biodegradable, and thermosensitive PEC-loaded poly(organophosphazene) hydrogel has great potential to be used as an effective delivery system for a sustained release of hGH with improved patient compliance. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.jconrel.2010.07.126
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 9
        StartPage: 359
    Subjects:
      – SubjectFull: Controlled release drugs
        Type: general
      – SubjectFull: Human growth hormone
        Type: general
      – SubjectFull: Polyelectrolytes
        Type: general
      – SubjectFull: Polyphosphazenes
        Type: general
      – SubjectFull: Polymer solutions
        Type: general
      – SubjectFull: Patient compliance
        Type: general
      – SubjectFull: Pharmacokinetics
        Type: general
      – SubjectFull: Polymer colloids
        Type: general
    Titles:
      – TitleFull: Sustained delivery of human growth hormone using a polyelectrolyte complex-loaded thermosensitive polyphosphazene hydrogel
        Type: main
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          Name:
            NameFull: Park, Mi-Ran
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            NameFull: Chun, ChangJu
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            NameFull: Ahn, Sung-Won
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            NameFull: Ki, Min-Hyo
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            NameFull: Cho, Chong-Su
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            NameFull: Song, Soo-Chang
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            – D: 01
              M: 11
              Text: Nov2010
              Type: published
              Y: 2010
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              Value: 01683659
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              Value: 147
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              Value: 3
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            – TitleFull: Journal of Controlled Release
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