Gastrointestinal tolerance of gamma-cyclodextrin in humans.
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| Title: | Gastrointestinal tolerance of gamma-cyclodextrin in humans. |
|---|---|
| Authors: | Koutsou, G. A., Storey, D. M., Bar, A. |
| Source: | Food Additives & Contaminants. Jul99, Vol. 16 Issue 7, p313-317. 5p. 2 Charts. |
| Subjects: | Cyclodextrins, Food additives |
| Abstract: | The gastrointenstinal tolerance of gamma-cyclodextrin (gammaCD) was examined in 24 healthy human volunteers. In a double-blind, placebo-controlled, randomized crossover study, single acute doses of 8g maltodextrin (placebo) or 8g gamma-CD (test) were consumed as a mid-morning snack after addition to 100g yogurt. Gastrointenstinal symptoms as well as frequency and consistency of stools were recorded before and after lunch at between 3-4 and 7-8h after intake respectively. The perception of the symptoms was rated on a subjective scale ranging from 1 ('more than normal') to 3('exceptionally more than normal'). Following consumption of maltodextrin, five subjects reported a total of 12 symptoms of which seven, two and three were rated as having grade 1, 2 and 3, respectively. Following consumption of gamma-CD, five subjects reported six symptoms all of which were graded as 1. Two subjects reported flatulence, which is a frequent consequence of the consumption of malabsorbed carbohydrates, after placebo and test treatment. The incidence of individual and combined side-effects as well as the number and consistency of faeces passed was not significantly different between placebo and test treatment. It is concluded that single doses of 8g gamma-CD and maltodextrin are tolerated equally well. This is in keeping with a good digestibility of gamma-CD by salivary and pancreatic amylase. [ABSTRACT FROM AUTHOR] |
| Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 5513722 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Gastrointestinal tolerance of gamma-cyclodextrin in humans. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Koutsou%2C+G%2E+A%2E%22">Koutsou, G. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Storey%2C+D%2E+M%2E%22">Storey, D. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Bar%2C+A%2E%22">Bar, A.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Food+Additives+%26+Contaminants%22">Food Additives & Contaminants</searchLink>. Jul99, Vol. 16 Issue 7, p313-317. 5p. 2 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Cyclodextrins%22">Cyclodextrins</searchLink><br /><searchLink fieldCode="DE" term="%22Food+additives%22">Food additives</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The gastrointenstinal tolerance of gamma-cyclodextrin (gammaCD) was examined in 24 healthy human volunteers. In a double-blind, placebo-controlled, randomized crossover study, single acute doses of 8g maltodextrin (placebo) or 8g gamma-CD (test) were consumed as a mid-morning snack after addition to 100g yogurt. Gastrointenstinal symptoms as well as frequency and consistency of stools were recorded before and after lunch at between 3-4 and 7-8h after intake respectively. The perception of the symptoms was rated on a subjective scale ranging from 1 ('more than normal') to 3('exceptionally more than normal'). Following consumption of maltodextrin, five subjects reported a total of 12 symptoms of which seven, two and three were rated as having grade 1, 2 and 3, respectively. Following consumption of gamma-CD, five subjects reported six symptoms all of which were graded as 1. Two subjects reported flatulence, which is a frequent consequence of the consumption of malabsorbed carbohydrates, after placebo and test treatment. The incidence of individual and combined side-effects as well as the number and consistency of faeces passed was not significantly different between placebo and test treatment. It is concluded that single doses of 8g gamma-CD and maltodextrin are tolerated equally well. This is in keeping with a good digestibility of gamma-CD by salivary and pancreatic amylase. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/026520399283984 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 313 Subjects: – SubjectFull: Cyclodextrins Type: general – SubjectFull: Food additives Type: general Titles: – TitleFull: Gastrointestinal tolerance of gamma-cyclodextrin in humans. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Koutsou, G. A. – PersonEntity: Name: NameFull: Storey, D. M. – PersonEntity: Name: NameFull: Bar, A. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul99 Type: published Y: 1999 Identifiers: – Type: issn-print Value: 0265203X Numbering: – Type: volume Value: 16 – Type: issue Value: 7 Titles: – TitleFull: Food Additives & Contaminants Type: main |
| ResultId | 1 |
