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Langmuir−Blodgett Films of Fluorinated Glycolipids and Polymerizable Lipids and Their Phase Separating Behavior.

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Title: Langmuir−Blodgett Films of Fluorinated Glycolipids and Polymerizable Lipids and Their Phase Separating Behavior.
Authors: Patrick Scheibe1, Jerome Schoenhentz1, Tobias Platen1, Anja Hoffmann-Röder1, Rudolf Zentel1
Source: Langmuir. Dec2010, Vol. 26 Issue 23, p18246-18255. 10p.
Subjects: Multilayered thin films, Fluorination, Glycolipids, Polymerization, Phase separation method (Engineering), Mixtures, Glycopeptides, Hydrophobic surfaces
Abstract: This paper describes the phase separating behavior of Langmuir monolayers from mixtures of different lipids that (i) either carry already a glycopeptide recognition site or can be easily modified to carry one and (ii) polymerizable lipids. To ensure demixing during compression, we used fluorinated lipids for the biological headgroups and hydrocarbon based lipids as polymerizable lipids. As a representative for a lipid monomer, which can be polymerized in the hydrophilic headgroup, a methacrylic monomer was used. As a monomer, which can be polymerized in the hydrophobic tail, a lipid with a diacetylene unit was used (pentacosadiynoic acid, PDA). The fluorinated lipids were on the one hand a perfluorinated lipid with three chains and on the other hand a partially fluorinated lipid with a TN-antigen headgroup. The macroscopic phase separation was observed by Brewster angle microscopy, whereas the phase separation on the nanoscale level was observed by atomic force microscopy. It turned out that all lipid mixtures showed (at least) a partial miscibility of the hydrocarbon compounds in the fluorinated compounds. This is positive for pattern formation, as it allows the formation of small demixed 2D patterned structures during crystallization from the homogeneous phase. For miscibility especially a liquid analogue phase proved to be advantageous. As lipid 3with three fluorinated lipid chains (very stable monolayer) is miscible with the polymerizable lipids 1and 2, it was mostly used for further investigations. For all three lipid mixtures, a phase separation on both the micrometer and the nanometer level was observed. The size of the crystalline domains could be controlled not only by varying the surface pressure but also by varying the molar composition of the mixtures. Furthermore, we showed that the binary mixture can be stabilized via UV polymerization. After polymerization and subsequent expansion of the barriers, the locked-in polymerized structures are stable even at low surface pressures (10 mN/m), where the unpolymerized mixture did not show any segregation. [ABSTRACT FROM AUTHOR]
Copyright of Langmuir is the property of American Chemical Society and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Langmuir−Blodgett Films of Fluorinated Glycolipids and Polymerizable Lipids and Their Phase Separating Behavior.
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  Data: <searchLink fieldCode="JN" term="%22Langmuir%22">Langmuir</searchLink>. Dec2010, Vol. 26 Issue 23, p18246-18255. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Multilayered+thin+films%22">Multilayered thin films</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorination%22">Fluorination</searchLink><br /><searchLink fieldCode="DE" term="%22Glycolipids%22">Glycolipids</searchLink><br /><searchLink fieldCode="DE" term="%22Polymerization%22">Polymerization</searchLink><br /><searchLink fieldCode="DE" term="%22Phase+separation+method+%28Engineering%29%22">Phase separation method (Engineering)</searchLink><br /><searchLink fieldCode="DE" term="%22Mixtures%22">Mixtures</searchLink><br /><searchLink fieldCode="DE" term="%22Glycopeptides%22">Glycopeptides</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrophobic+surfaces%22">Hydrophobic surfaces</searchLink>
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  Data: This paper describes the phase separating behavior of Langmuir monolayers from mixtures of different lipids that (i) either carry already a glycopeptide recognition site or can be easily modified to carry one and (ii) polymerizable lipids. To ensure demixing during compression, we used fluorinated lipids for the biological headgroups and hydrocarbon based lipids as polymerizable lipids. As a representative for a lipid monomer, which can be polymerized in the hydrophilic headgroup, a methacrylic monomer was used. As a monomer, which can be polymerized in the hydrophobic tail, a lipid with a diacetylene unit was used (pentacosadiynoic acid, PDA). The fluorinated lipids were on the one hand a perfluorinated lipid with three chains and on the other hand a partially fluorinated lipid with a TN-antigen headgroup. The macroscopic phase separation was observed by Brewster angle microscopy, whereas the phase separation on the nanoscale level was observed by atomic force microscopy. It turned out that all lipid mixtures showed (at least) a partial miscibility of the hydrocarbon compounds in the fluorinated compounds. This is positive for pattern formation, as it allows the formation of small demixed 2D patterned structures during crystallization from the homogeneous phase. For miscibility especially a liquid analogue phase proved to be advantageous. As lipid 3with three fluorinated lipid chains (very stable monolayer) is miscible with the polymerizable lipids 1and 2, it was mostly used for further investigations. For all three lipid mixtures, a phase separation on both the micrometer and the nanometer level was observed. The size of the crystalline domains could be controlled not only by varying the surface pressure but also by varying the molar composition of the mixtures. Furthermore, we showed that the binary mixture can be stabilized via UV polymerization. After polymerization and subsequent expansion of the barriers, the locked-in polymerized structures are stable even at low surface pressures (10 mN/m), where the unpolymerized mixture did not show any segregation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Langmuir is the property of American Chemical Society and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1021/la1029917
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 10
        StartPage: 18246
    Subjects:
      – SubjectFull: Multilayered thin films
        Type: general
      – SubjectFull: Fluorination
        Type: general
      – SubjectFull: Glycolipids
        Type: general
      – SubjectFull: Polymerization
        Type: general
      – SubjectFull: Phase separation method (Engineering)
        Type: general
      – SubjectFull: Mixtures
        Type: general
      – SubjectFull: Glycopeptides
        Type: general
      – SubjectFull: Hydrophobic surfaces
        Type: general
    Titles:
      – TitleFull: Langmuir−Blodgett Films of Fluorinated Glycolipids and Polymerizable Lipids and Their Phase Separating Behavior.
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            NameFull: Patrick Scheibe
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            NameFull: Tobias Platen
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            NameFull: Anja Hoffmann-Röder
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            – D: 07
              M: 12
              Text: Dec2010
              Type: published
              Y: 2010
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              Value: 26
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              Value: 23
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