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VARIATIONS OF SOME PARAMETERS OF ENZYME INDUCTION IN CHEMICAL WORKERS.

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Title: VARIATIONS OF SOME PARAMETERS OF ENZYME INDUCTION IN CHEMICAL WORKERS.
Authors: DOLARA, P.1, LODOVICI, M.1, BUFFONI, F.1, BUIATTI, E.2, BACCETTI, S.2, CIOFINI, O.2, BAVAZZANO, P.2, BARCHIELLI, S.2, VANNUCCI, V.2
Source: Annals of Occupational Hygiene. 01/01/1982, Vol. 25 Issue 1, p27-32. 6p.
Abstract: Several parameters related to mono-oxygenase activity were followed in a population of chemical workers and controls. Workers exposed to toluene and xylene had a significant increase of urinary glucaric acid, that was correlated with hippuric acid excretion. On the other hand, workers exposed to pigments showed a marked increase of antipyrine half-life. A dose-related decrease of liver -demethylase was induced in rats by the administration of a mixture of three of the pigments in use in the plant. Serum gamma-glutamyltranspeptidase was decreased in the workers exposed to pigments, but this variation was not statistically significant. The exposure to different chemicals in the workplace seemed to induce a complicated variation of mono-oxygenase levels, some enzyme being inhibited and others induced in the same group of workers. The sensitivity of these workers to toxic effects of chemicals, carcinogenic compounds and drugs seems to differ markedly from the control population. [ABSTRACT FROM PUBLISHER]
Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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  Data: VARIATIONS OF SOME PARAMETERS OF ENZYME INDUCTION IN CHEMICAL WORKERS.
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  Data: <searchLink fieldCode="AR" term="%22DOLARA%2C+P%2E%22">DOLARA, P.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22LODOVICI%2C+M%2E%22">LODOVICI, M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22BUFFONI%2C+F%2E%22">BUFFONI, F.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22BUIATTI%2C+E%2E%22">BUIATTI, E.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22BACCETTI%2C+S%2E%22">BACCETTI, S.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22CIOFINI%2C+O%2E%22">CIOFINI, O.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22BAVAZZANO%2C+P%2E%22">BAVAZZANO, P.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22BARCHIELLI%2C+S%2E%22">BARCHIELLI, S.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22VANNUCCI%2C+V%2E%22">VANNUCCI, V.</searchLink><relatesTo>2</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Annals+of+Occupational+Hygiene%22">Annals of Occupational Hygiene</searchLink>. 01/01/1982, Vol. 25 Issue 1, p27-32. 6p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Several parameters related to mono-oxygenase activity were followed in a population of chemical workers and controls. Workers exposed to toluene and xylene had a significant increase of urinary glucaric acid, that was correlated with hippuric acid excretion. On the other hand, workers exposed to pigments showed a marked increase of antipyrine half-life. A dose-related decrease of liver -demethylase was induced in rats by the administration of a mixture of three of the pigments in use in the plant. Serum gamma-glutamyltranspeptidase was decreased in the workers exposed to pigments, but this variation was not statistically significant. The exposure to different chemicals in the workplace seemed to induce a complicated variation of mono-oxygenase levels, some enzyme being inhibited and others induced in the same group of workers. The sensitivity of these workers to toxic effects of chemicals, carcinogenic compounds and drugs seems to differ markedly from the control population. [ABSTRACT FROM PUBLISHER]
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  Data: <i>Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: 01/01/1982
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