T1-2 anal carcinoma requires elective inguinal radiation treatment – The results of Trans Tasman Radiation Oncology Group study TROG 99.02
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| Title: | T1-2 anal carcinoma requires elective inguinal radiation treatment – The results of Trans Tasman Radiation Oncology Group study TROG 99.02 |
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| Authors: | Matthews, John H.L.1 johnmatt@ihug.co.nz, Burmeister, Bryan H.2, Borg, Martin3, Capp, Anne L.4, Joseph, David5, Thompson, Kerin M.1, Thompson, Paul I.6, Harvey, Jennifer A.7, Spry, Nigel A.8 |
| Source: | Radiotherapy & Oncology. Jan2011, Vol. 98 Issue 1, p93-98. 6p. |
| Subjects: | Cancer radiotherapy, Anal cancer treatment, Cancer chemotherapy, Fluorouracil, Survival analysis (Biometry), Mitomycin C |
| Abstract: | Abstract: Background and purpose: Elective inguinal irradiation increases morbidity. We describe outcomes of moderate intensity chemoradiation treating anal canal and adjacent pelvic nodes only. Material and methods: Forty patients with T1-2, N0 anal carcinoma were enrolled between March 1999 and March 2003. Inguinal nodes were NOT electively irradiated. The anal canal and regional pelvic nodes received 36Gy/20# over 4weeks, and 2weeks later the anal canal was boosted with 14.4Gy/8#. Chemotherapy was 5 fluorouracil 800mg/m2/day on days 1–4 and 36–39, and Mitomycin C 10mg/m2 on day 1. Results: Median follow-up was 44months. Complete response was 95%. Four year results were; overall survival 71%, local control 82%, and colostomy-free survival (including salvage) 85%. Inguinal failure occurred in 22.5% but was isolated in only 12.5%. Treatment was well tolerated acutely with no toxic deaths. Severe late toxicity occurred in 7.5%. Conclusions: This moderate dose ‘non inguinal’ chemoradiation regimen resulted in modest acute toxicity, minimal long term morbidity and local control in line with other series. However staging failed to identify 12.5% of patients whose isolated inguinal failure might have been prevented by elective irradiation. Without more effective staging, all patients should receive elective inguinal irradiation. [ABSTRACT FROM AUTHOR] |
| Copyright of Radiotherapy & Oncology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 57368646 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: T1-2 anal carcinoma requires elective inguinal radiation treatment – The results of Trans Tasman Radiation Oncology Group study TROG 99.02 – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Matthews%2C+John+H%2EL%2E%22">Matthews, John H.L.</searchLink><relatesTo>1</relatesTo><i> johnmatt@ihug.co.nz</i><br /><searchLink fieldCode="AR" term="%22Burmeister%2C+Bryan+H%2E%22">Burmeister, Bryan H.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Borg%2C+Martin%22">Borg, Martin</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Capp%2C+Anne+L%2E%22">Capp, Anne L.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Joseph%2C+David%22">Joseph, David</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Thompson%2C+Kerin+M%2E%22">Thompson, Kerin M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Thompson%2C+Paul+I%2E%22">Thompson, Paul I.</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Harvey%2C+Jennifer+A%2E%22">Harvey, Jennifer A.</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Spry%2C+Nigel+A%2E%22">Spry, Nigel A.</searchLink><relatesTo>8</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Radiotherapy+%26+Oncology%22">Radiotherapy & Oncology</searchLink>. Jan2011, Vol. 98 Issue 1, p93-98. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Cancer+radiotherapy%22">Cancer radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Anal+cancer+treatment%22">Anal cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+chemotherapy%22">Cancer chemotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorouracil%22">Fluorouracil</searchLink><br /><searchLink fieldCode="DE" term="%22Survival+analysis+%28Biometry%29%22">Survival analysis (Biometry)</searchLink><br /><searchLink fieldCode="DE" term="%22Mitomycin+C%22">Mitomycin C</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract: Background and purpose: Elective inguinal irradiation increases morbidity. We describe outcomes of moderate intensity chemoradiation treating anal canal and adjacent pelvic nodes only. Material and methods: Forty patients with T1-2, N0 anal carcinoma were enrolled between March 1999 and March 2003. Inguinal nodes were NOT electively irradiated. The anal canal and regional pelvic nodes received 36Gy/20# over 4weeks, and 2weeks later the anal canal was boosted with 14.4Gy/8#. Chemotherapy was 5 fluorouracil 800mg/m2/day on days 1–4 and 36–39, and Mitomycin C 10mg/m2 on day 1. Results: Median follow-up was 44months. Complete response was 95%. Four year results were; overall survival 71%, local control 82%, and colostomy-free survival (including salvage) 85%. Inguinal failure occurred in 22.5% but was isolated in only 12.5%. Treatment was well tolerated acutely with no toxic deaths. Severe late toxicity occurred in 7.5%. Conclusions: This moderate dose ‘non inguinal’ chemoradiation regimen resulted in modest acute toxicity, minimal long term morbidity and local control in line with other series. However staging failed to identify 12.5% of patients whose isolated inguinal failure might have been prevented by elective irradiation. Without more effective staging, all patients should receive elective inguinal irradiation. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Radiotherapy & Oncology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.radonc.2010.10.005 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 93 Subjects: – SubjectFull: Cancer radiotherapy Type: general – SubjectFull: Anal cancer treatment Type: general – SubjectFull: Cancer chemotherapy Type: general – SubjectFull: Fluorouracil Type: general – SubjectFull: Survival analysis (Biometry) Type: general – SubjectFull: Mitomycin C Type: general Titles: – TitleFull: T1-2 anal carcinoma requires elective inguinal radiation treatment – The results of Trans Tasman Radiation Oncology Group study TROG 99.02 Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Matthews, John H.L. – PersonEntity: Name: NameFull: Burmeister, Bryan H. – PersonEntity: Name: NameFull: Borg, Martin – PersonEntity: Name: NameFull: Capp, Anne L. – PersonEntity: Name: NameFull: Joseph, David – PersonEntity: Name: NameFull: Thompson, Kerin M. – PersonEntity: Name: NameFull: Thompson, Paul I. – PersonEntity: Name: NameFull: Harvey, Jennifer A. – PersonEntity: Name: NameFull: Spry, Nigel A. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2011 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 01678140 Numbering: – Type: volume Value: 98 – Type: issue Value: 1 Titles: – TitleFull: Radiotherapy & Oncology Type: main |
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