Modelling evolution and the evolving mechanical environment of saccular cerebral aneurysms.
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| Title: | Modelling evolution and the evolving mechanical environment of saccular cerebral aneurysms. |
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| Authors: | Watton, P. N.1 Paul.Watton@eng.ox.ac.uk, Selimovic, A.1, Raberger, N. B.2, Huang, P.1, Holzapfel, G. A.3,4, Ventikos, Y.1 |
| Source: | Biomechanics & Modeling in Mechanobiology. Feb2011, Vol. 10 Issue 1, p109-132. 24p. |
| Abstract: | fluid-solid-growth (FSG) model of saccular cerebral aneurysm evolution is developed. It utilises a realistic two-layered structural model of the internal carotid artery and explicitly accounts for the degradation of the elastinous constituents and growth and remodelling (G&R) of the collagen fabric. Aneurysm inception is prescribed: a localised degradation of elastin results in a perturbation in the arterial geometry; the collagen fabric adapts, and the artery achieves a new homeostatic configuration. The perturbation to the geometry creates an altered haemodynamic environment. Subsequent degradation of elastin is explicitly linked to low wall shear stress (WSS) in a confined region of the arterial domain. A sidewall saccular aneurysm develops, the collagen fabric adapts and the aneurysm stabilises in size. A quasi-static analysis is performed to determine the geometry at diastolic pressure. This enables the cyclic stretching of the tissue to be quantified, and we propose a novel index to quantify the degree of biaxial stretching of the tissue. Whilst growth is linked to low WSS from a steady (systolic) flow analysis, a pulsatile flow analysis is performed to compare steady and pulsatile flow parameters during evolution. This model illustrates the evolving mechanical environment for an idealised saccular cerebral aneurysm developing on a cylindrical parent artery and provides the guidance to more sophisticated FSG models of aneurysm evolution which link G&R to the local mechanical stimuli of vascular cells. [ABSTRACT FROM AUTHOR] |
| Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 57529997 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10237-010-0221-y Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 24 StartPage: 109 Titles: – TitleFull: Modelling evolution and the evolving mechanical environment of saccular cerebral aneurysms. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Watton, P. N. – PersonEntity: Name: NameFull: Selimovic, A. – PersonEntity: Name: NameFull: Raberger, N. B. – PersonEntity: Name: NameFull: Huang, P. – PersonEntity: Name: NameFull: Holzapfel, G. A. – PersonEntity: Name: NameFull: Ventikos, Y. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2011 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 16177959 Numbering: – Type: volume Value: 10 – Type: issue Value: 1 Titles: – TitleFull: Biomechanics & Modeling in Mechanobiology Type: main |
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