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A novel chitosan/polyoxometalate nano-complex for anti-cancer applications

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Title: A novel chitosan/polyoxometalate nano-complex for anti-cancer applications
Authors: Menon, Deepthy1 deepsmenon@gmail.com, Thomas, Reny Thankam1, Narayanan, Sreeja1, Maya, S.1, Jayakumar, R.1, Hussain, Firasat2,3, Lakshmanan, Vinoth-Kumar1, Nair, S.V.1
Source: Carbohydrate Polymers. Mar2011, Vol. 84 Issue 3, p887-893. 7p.
Subjects: Chitosan, Polyoxometalates, Antineoplastic agents, Molecular weights, Biocompatibility, Fluorescence spectroscopy, Cancer cells, Cell-mediated cytotoxicity, Complex compounds, Gelation, Flow cytometry
Abstract: Abstract: Polyoxometalates (POMs) show great molecular diversity and have significant applications in material science as well as in medicine. In this study, nano-complexation of a novel europium containing polyanion [Cs⊂Eu6As6W63O218(H2O)14(OH)4]25− (EuWAs) with biocompatible chitosan was achieved through ionotropic gelation technique without the aid of any cross-linker. Thus obtained chitosan/EuWAs nano-complex was characterized using DLS and Zeta analysis, FT-IR, SEM, AFM, TG/DTA, EDAX and fluorescence spectroscopy. The cross-linking efficiency of EuWAs with chitosan was calculated to be 81% and the release profile recorded at physiological pH was slow and sustained. Cytotoxicity assays performed on a host of cancer cell lines, viz., KB, MCF-7, PC-3 and A549 proved the anticancer activity of the nanocomplex and flow cytometry studies revealed that reactive oxygen species generation can be the plausible mechanism for the apoptosis induced by this material. Our study has thus indicated the feasibility of using chitosan/EuWAs nano-complex for anticancer applications. [Copyright &y& Elsevier]
Copyright of Carbohydrate Polymers is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 58097029
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: A novel chitosan/polyoxometalate nano-complex for anti-cancer applications
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  Data: <searchLink fieldCode="AR" term="%22Menon%2C+Deepthy%22">Menon, Deepthy</searchLink><relatesTo>1</relatesTo><i> deepsmenon@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Thomas%2C+Reny+Thankam%22">Thomas, Reny Thankam</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Narayanan%2C+Sreeja%22">Narayanan, Sreeja</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Maya%2C+S%2E%22">Maya, S.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Jayakumar%2C+R%2E%22">Jayakumar, R.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hussain%2C+Firasat%22">Hussain, Firasat</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Lakshmanan%2C+Vinoth-Kumar%22">Lakshmanan, Vinoth-Kumar</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Nair%2C+S%2EV%2E%22">Nair, S.V.</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Carbohydrate+Polymers%22">Carbohydrate Polymers</searchLink>. Mar2011, Vol. 84 Issue 3, p887-893. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Chitosan%22">Chitosan</searchLink><br /><searchLink fieldCode="DE" term="%22Polyoxometalates%22">Polyoxometalates</searchLink><br /><searchLink fieldCode="DE" term="%22Antineoplastic+agents%22">Antineoplastic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+weights%22">Molecular weights</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorescence+spectroscopy%22">Fluorescence spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+cells%22">Cancer cells</searchLink><br /><searchLink fieldCode="DE" term="%22Cell-mediated+cytotoxicity%22">Cell-mediated cytotoxicity</searchLink><br /><searchLink fieldCode="DE" term="%22Complex+compounds%22">Complex compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Gelation%22">Gelation</searchLink><br /><searchLink fieldCode="DE" term="%22Flow+cytometry%22">Flow cytometry</searchLink>
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  Data: Abstract: Polyoxometalates (POMs) show great molecular diversity and have significant applications in material science as well as in medicine. In this study, nano-complexation of a novel europium containing polyanion [Cs⊂Eu6As6W63O218(H2O)14(OH)4]25− (EuWAs) with biocompatible chitosan was achieved through ionotropic gelation technique without the aid of any cross-linker. Thus obtained chitosan/EuWAs nano-complex was characterized using DLS and Zeta analysis, FT-IR, SEM, AFM, TG/DTA, EDAX and fluorescence spectroscopy. The cross-linking efficiency of EuWAs with chitosan was calculated to be 81% and the release profile recorded at physiological pH was slow and sustained. Cytotoxicity assays performed on a host of cancer cell lines, viz., KB, MCF-7, PC-3 and A549 proved the anticancer activity of the nanocomplex and flow cytometry studies revealed that reactive oxygen species generation can be the plausible mechanism for the apoptosis induced by this material. Our study has thus indicated the feasibility of using chitosan/EuWAs nano-complex for anticancer applications. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Carbohydrate Polymers is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.carbpol.2010.12.030
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        Text: English
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      – SubjectFull: Chitosan
        Type: general
      – SubjectFull: Polyoxometalates
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      – SubjectFull: Antineoplastic agents
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      – SubjectFull: Molecular weights
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      – SubjectFull: Complex compounds
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      – SubjectFull: Gelation
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      – SubjectFull: Flow cytometry
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              Text: Mar2011
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