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A perfluoropolyether corneal inlay for the correction of refractive error

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Title: A perfluoropolyether corneal inlay for the correction of refractive error
Authors: Evans, Margaret D.M.1,2 meg.evans@csiro.au, Prakasam, Ruby K.1,3, Vaddavalli, Pravin K.1,3, Hughes, Timothy C.1,4, Knower, Warren1,4, Wilkie, John S.1,4, McLean, Keith M.1,4, Johnson, Graham1,2, McFarland, Gail A.1,2, Xie, Ruo Zhong1,5, Sweeney, Deborah F.1,5
Source: Biomaterials. Apr2011, Vol. 32 Issue 12, p3158-3165. 8p.
Subjects: Treatment of eye refractive errors, Polyethers, Medical polymers, Cornea, Biocompatibility, Fluoropolymers, Ophthalmology
Abstract: Abstract: This study assessed the long-term biological response of a perfluoropolyether-based polymer developed as a corneal inlay to correct refractive error. The polymer formulation met chemical and physical specifications and was non-cytotoxic when tested using standard in vitro techniques. It was cast into small microporous membranes that were implanted as inlays into corneas of rabbits (n = 5) and unsighted humans (n = 5 + 1 surgical control) which were monitored for up to 23 and 48 months respectively. Overall, the inlays were well tolerated during study period with the corneas remaining clear and holding a normal tear film and with no increased vascularisation or redness recorded. Inlays in three human corneas continued past 48 months without sequelae. Inlays in two human corneas were removed early due to small, focal erosions developing 5 and 24 months post-implantation. Polymer inlays maintained their integrity and corneal position for the study duration although the optical clarity of the inlays reduced slowly with time. Inlays induced corneal curvature changes in human subjects that showed stability with time and the refractive effect was reversed when the inlay was removed. Outcomes showed the potential of a perfluoropolyether inlay as a biologically acceptable corneal implant with which to provide stable correction of refractive error. [Copyright &y& Elsevier]
Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 58588644
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: A perfluoropolyether corneal inlay for the correction of refractive error
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  Data: <searchLink fieldCode="AR" term="%22Evans%2C+Margaret+D%2EM%2E%22">Evans, Margaret D.M.</searchLink><relatesTo>1,2</relatesTo><i> meg.evans@csiro.au</i><br /><searchLink fieldCode="AR" term="%22Prakasam%2C+Ruby+K%2E%22">Prakasam, Ruby K.</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Vaddavalli%2C+Pravin+K%2E%22">Vaddavalli, Pravin K.</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Hughes%2C+Timothy+C%2E%22">Hughes, Timothy C.</searchLink><relatesTo>1,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Knower%2C+Warren%22">Knower, Warren</searchLink><relatesTo>1,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Wilkie%2C+John+S%2E%22">Wilkie, John S.</searchLink><relatesTo>1,4</relatesTo><br /><searchLink fieldCode="AR" term="%22McLean%2C+Keith+M%2E%22">McLean, Keith M.</searchLink><relatesTo>1,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Johnson%2C+Graham%22">Johnson, Graham</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22McFarland%2C+Gail+A%2E%22">McFarland, Gail A.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Xie%2C+Ruo+Zhong%22">Xie, Ruo Zhong</searchLink><relatesTo>1,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Sweeney%2C+Deborah+F%2E%22">Sweeney, Deborah F.</searchLink><relatesTo>1,5</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Biomaterials%22">Biomaterials</searchLink>. Apr2011, Vol. 32 Issue 12, p3158-3165. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Treatment+of+eye+refractive+errors%22">Treatment of eye refractive errors</searchLink><br /><searchLink fieldCode="DE" term="%22Polyethers%22">Polyethers</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+polymers%22">Medical polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Cornea%22">Cornea</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Fluoropolymers%22">Fluoropolymers</searchLink><br /><searchLink fieldCode="DE" term="%22Ophthalmology%22">Ophthalmology</searchLink>
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  Data: Abstract: This study assessed the long-term biological response of a perfluoropolyether-based polymer developed as a corneal inlay to correct refractive error. The polymer formulation met chemical and physical specifications and was non-cytotoxic when tested using standard in vitro techniques. It was cast into small microporous membranes that were implanted as inlays into corneas of rabbits (n = 5) and unsighted humans (n = 5 + 1 surgical control) which were monitored for up to 23 and 48 months respectively. Overall, the inlays were well tolerated during study period with the corneas remaining clear and holding a normal tear film and with no increased vascularisation or redness recorded. Inlays in three human corneas continued past 48 months without sequelae. Inlays in two human corneas were removed early due to small, focal erosions developing 5 and 24 months post-implantation. Polymer inlays maintained their integrity and corneal position for the study duration although the optical clarity of the inlays reduced slowly with time. Inlays induced corneal curvature changes in human subjects that showed stability with time and the refractive effect was reversed when the inlay was removed. Outcomes showed the potential of a perfluoropolyether inlay as a biologically acceptable corneal implant with which to provide stable correction of refractive error. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.biomaterials.2011.01.047
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      – SubjectFull: Polyethers
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      – SubjectFull: Medical polymers
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