Bibliographic Details
| Title: |
New two-step sequence involving a hetero-Diels–Alder and a nonphenolic oxidative coupling reaction: a convergent access to analogs of steganacin |
| Authors: |
Laurent, Mathieu Y. mathieu.laurent@univ-lemans.fr, Stocker, Vivien1, Temgoua, Valéry Momo1, Dujardin, Gilles1, Dhal, Robert1 |
| Source: |
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Apr2011, Vol. 52 Issue 14, p1608-1611. 4p. |
| Subjects: |
Diels-Alder reaction, Phenols, Oxidation-reduction reaction, Furans, Antimitotic agents, Stereochemistry, Lignans |
| Abstract: |
Abstract: A new family of analogs of steganacin, an important antimitotic compound, was accessed. It takes advantage of a completely stereoselective sequence of two key steps. The central dihydropyrane core is built by a highly diastereoselective and facially controlled hetero-Diels–Alder reaction. It is followed by a nonphenolic biaryl oxidative coupling with a complete atropo-stereoselectivity. It leads to a quick way to form cyclic biaryl lignans. [Copyright &y& Elsevier] |
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| Database: |
Engineering Source |
