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Tenascin-C triggers fibrin accumulation by downregulation of tissue plasminogen activator

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Title: Tenascin-C triggers fibrin accumulation by downregulation of tissue plasminogen activator
Authors: Brellier, Florence1 florence.brellier@fmi.ch, Hostettler, Katrin2, Hotz, Hans-Rudolf1, Ozcakir, Ceyda3, Çöloğlu, Sedat A.4, Togbe, Dieudonnée5, Ryffel, Bernard5, Roth, Michael2, Chiquet-Ehrismann, Ruth1
Source: FEBS Letters. Mar2011, Vol. 585 Issue 6, p913-920. 8p.
Subjects: Tenascin, Fibrin, Tissue plasminogen activator, Extracellular matrix, Fibroblasts, Laboratory mice, Polymerase chain reaction, Gene expression, Fibrosis, Asthma, Cancer
Abstract: Abstract: We explored novel functions of tenascin-C by comparing mouse embryonic fibroblasts (MEFs) proficient or deficient in tenascin-C expression. Transcript profiling analysis identified tissue plasminogen activator (tPA) as the most consistently over-expressed gene in all tenascin-C deficient MEFs. This was confirmed by real-time PCR as well as by protein expression analysis. In agreement with these observations, tenascin-C deficient MEFs had an increased capacity to digest fibrin in situ. Consistently, tenascin-C expression in vivo was found to correlate with fibrin deposition in several diseases associated with tenascin-C overexpression such as fibrosis, asthma and cancer. In conclusion, the present study suggests a new role of tenascin-C as a regulator of the fibrinolytic system. [Copyright &y& Elsevier]
Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 59327688
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Tenascin-C triggers fibrin accumulation by downregulation of tissue plasminogen activator
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  Data: <searchLink fieldCode="AR" term="%22Brellier%2C+Florence%22">Brellier, Florence</searchLink><relatesTo>1</relatesTo><i> florence.brellier@fmi.ch</i><br /><searchLink fieldCode="AR" term="%22Hostettler%2C+Katrin%22">Hostettler, Katrin</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Hotz%2C+Hans-Rudolf%22">Hotz, Hans-Rudolf</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ozcakir%2C+Ceyda%22">Ozcakir, Ceyda</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Çöloğlu%2C+Sedat+A%2E%22">Çöloğlu, Sedat A.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Togbe%2C+Dieudonnée%22">Togbe, Dieudonnée</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Ryffel%2C+Bernard%22">Ryffel, Bernard</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Roth%2C+Michael%22">Roth, Michael</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Chiquet-Ehrismann%2C+Ruth%22">Chiquet-Ehrismann, Ruth</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22FEBS+Letters%22">FEBS Letters</searchLink>. Mar2011, Vol. 585 Issue 6, p913-920. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Tenascin%22">Tenascin</searchLink><br /><searchLink fieldCode="DE" term="%22Fibrin%22">Fibrin</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+plasminogen+activator%22">Tissue plasminogen activator</searchLink><br /><searchLink fieldCode="DE" term="%22Extracellular+matrix%22">Extracellular matrix</searchLink><br /><searchLink fieldCode="DE" term="%22Fibroblasts%22">Fibroblasts</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink><br /><searchLink fieldCode="DE" term="%22Polymerase+chain+reaction%22">Polymerase chain reaction</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Fibrosis%22">Fibrosis</searchLink><br /><searchLink fieldCode="DE" term="%22Asthma%22">Asthma</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer%22">Cancer</searchLink>
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  Data: Abstract: We explored novel functions of tenascin-C by comparing mouse embryonic fibroblasts (MEFs) proficient or deficient in tenascin-C expression. Transcript profiling analysis identified tissue plasminogen activator (tPA) as the most consistently over-expressed gene in all tenascin-C deficient MEFs. This was confirmed by real-time PCR as well as by protein expression analysis. In agreement with these observations, tenascin-C deficient MEFs had an increased capacity to digest fibrin in situ. Consistently, tenascin-C expression in vivo was found to correlate with fibrin deposition in several diseases associated with tenascin-C overexpression such as fibrosis, asthma and cancer. In conclusion, the present study suggests a new role of tenascin-C as a regulator of the fibrinolytic system. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.febslet.2011.02.023
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      – Code: eng
        Text: English
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        PageCount: 8
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      – SubjectFull: Tenascin
        Type: general
      – SubjectFull: Fibrin
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      – SubjectFull: Tissue plasminogen activator
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      – SubjectFull: Extracellular matrix
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      – SubjectFull: Fibroblasts
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      – SubjectFull: Laboratory mice
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      – SubjectFull: Polymerase chain reaction
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              Text: Mar2011
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