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Modification of the sugar specificity of a plant lectin: structural studies on a point mutant of Erythrina corallodendron lectin.

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Bibliographic Details
Title: Modification of the sugar specificity of a plant lectin: structural studies on a point mutant of Erythrina corallodendron lectin.
Authors: Thamotharan, Subbiah1, Karthikeyan, Tangavelou1, Kulkarni, Kiran A.1, Shetty, Kartika N.1, Surolia, Avadhesha1, Vijayan, Mamannamana1, Suguna, Kaza1 suguna@mbu.iisc.ernet.in
Source: Acta Crystallographica: Section D (Wiley-Blackwell). Mar2011, Vol. 67 Issue 3, p218-227. 10p. 5 Diagrams, 2 Charts, 1 Graph.
Subjects: Erythrina, Sugar, Lectins, Binding sites, Carbohydrates, Legumes
Abstract: The article provides information on a study which provided a structural perspective of the altered sugar specificity of Erythrina corallodendron lectin (EcorL). The research presented the crystal structure of a mutant legume lectin, which has provided the first structural view of an engineered carbohydrate-binding site. It also investigated the differences in the relative binding affinities of the wild-type and mutant towards the two sugars based on the structures.
Database: Engineering Source
Description
Abstract:The article provides information on a study which provided a structural perspective of the altered sugar specificity of Erythrina corallodendron lectin (EcorL). The research presented the crystal structure of a mutant legume lectin, which has provided the first structural view of an engineered carbohydrate-binding site. It also investigated the differences in the relative binding affinities of the wild-type and mutant towards the two sugars based on the structures.
ISSN:09074449
DOI:10.1107/S0907444911004525