View in EDS

Modification of the sugar specificity of a plant lectin: structural studies on a point mutant of Erythrina corallodendron lectin.

Saved in:
Bibliographic Details
Title: Modification of the sugar specificity of a plant lectin: structural studies on a point mutant of Erythrina corallodendron lectin.
Authors: Thamotharan, Subbiah1, Karthikeyan, Tangavelou1, Kulkarni, Kiran A.1, Shetty, Kartika N.1, Surolia, Avadhesha1, Vijayan, Mamannamana1, Suguna, Kaza1 suguna@mbu.iisc.ernet.in
Source: Acta Crystallographica: Section D (Wiley-Blackwell). Mar2011, Vol. 67 Issue 3, p218-227. 10p. 5 Diagrams, 2 Charts, 1 Graph.
Subjects: Erythrina, Sugar, Lectins, Binding sites, Carbohydrates, Legumes
Abstract: The article provides information on a study which provided a structural perspective of the altered sugar specificity of Erythrina corallodendron lectin (EcorL). The research presented the crystal structure of a mutant legume lectin, which has provided the first structural view of an engineered carbohydrate-binding site. It also investigated the differences in the relative binding affinities of the wild-type and mutant towards the two sugars based on the structures.
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 59706396
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Modification of the sugar specificity of a plant lectin: structural studies on a point mutant of Erythrina corallodendron lectin.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Thamotharan%2C+Subbiah%22">Thamotharan, Subbiah</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Karthikeyan%2C+Tangavelou%22">Karthikeyan, Tangavelou</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kulkarni%2C+Kiran+A%2E%22">Kulkarni, Kiran A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Shetty%2C+Kartika+N%2E%22">Shetty, Kartika N.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Surolia%2C+Avadhesha%22">Surolia, Avadhesha</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Vijayan%2C+Mamannamana%22">Vijayan, Mamannamana</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Suguna%2C+Kaza%22">Suguna, Kaza</searchLink><relatesTo>1</relatesTo><i> suguna@mbu.iisc.ernet.in</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Crystallographica%3A+Section+D+%28Wiley-Blackwell%29%22">Acta Crystallographica: Section D (Wiley-Blackwell)</searchLink>. Mar2011, Vol. 67 Issue 3, p218-227. 10p. 5 Diagrams, 2 Charts, 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Erythrina%22">Erythrina</searchLink><br /><searchLink fieldCode="DE" term="%22Sugar%22">Sugar</searchLink><br /><searchLink fieldCode="DE" term="%22Lectins%22">Lectins</searchLink><br /><searchLink fieldCode="DE" term="%22Binding+sites%22">Binding sites</searchLink><br /><searchLink fieldCode="DE" term="%22Carbohydrates%22">Carbohydrates</searchLink><br /><searchLink fieldCode="DE" term="%22Legumes%22">Legumes</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The article provides information on a study which provided a structural perspective of the altered sugar specificity of Erythrina corallodendron lectin (EcorL). The research presented the crystal structure of a mutant legume lectin, which has provided the first structural view of an engineered carbohydrate-binding site. It also investigated the differences in the relative binding affinities of the wild-type and mutant towards the two sugars based on the structures.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=59706396
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1107/S0907444911004525
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 218
    Subjects:
      – SubjectFull: Erythrina
        Type: general
      – SubjectFull: Sugar
        Type: general
      – SubjectFull: Lectins
        Type: general
      – SubjectFull: Binding sites
        Type: general
      – SubjectFull: Carbohydrates
        Type: general
      – SubjectFull: Legumes
        Type: general
    Titles:
      – TitleFull: Modification of the sugar specificity of a plant lectin: structural studies on a point mutant of Erythrina corallodendron lectin.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Thamotharan, Subbiah
      – PersonEntity:
          Name:
            NameFull: Karthikeyan, Tangavelou
      – PersonEntity:
          Name:
            NameFull: Kulkarni, Kiran A.
      – PersonEntity:
          Name:
            NameFull: Shetty, Kartika N.
      – PersonEntity:
          Name:
            NameFull: Surolia, Avadhesha
      – PersonEntity:
          Name:
            NameFull: Vijayan, Mamannamana
      – PersonEntity:
          Name:
            NameFull: Suguna, Kaza
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Text: Mar2011
              Type: published
              Y: 2011
          Identifiers:
            – Type: issn-print
              Value: 09074449
          Numbering:
            – Type: volume
              Value: 67
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Acta Crystallographica: Section D (Wiley-Blackwell)
              Type: main
ResultId 1