Bibliographic Details
| Title: |
Development and Characterization of Sodium Alginate-Hydroxypropyl Methylcellulose-Polyester Multilayered Hydrogel Membranes for Drug Delivery through Skin. |
| Authors: |
Kulkarni, Raghavendra V.1, Wagh, Yogesh J.1, Setty, C. Mallikarjun2, Sa, Biswanath3 |
| Source: |
Polymer-Plastics Technology & Engineering. Mar2011, Vol. 50 Issue 5, p490-497. 8p. 1 Black and White Photograph, 1 Diagram, 2 Charts, 7 Graphs. |
| Subjects: |
Sodium alginate, Cellulose, Polyesters, Artificial membranes, Drug delivery systems, Skin, Diethylamine, Anti-inflammatory agents, Permeability |
| Abstract: |
The multi-layered hydrogel membranes of sodium alginate-hydroxypropyl methylcellulose-polyester were developed for controlled delivery of anti-inflammatory drug, diclofenac diethylamine through intact skin. The XRD studies indicated the amorphous dispersion of drug in the membranes. DSC analysis suggested that as cross-linking increases, the stiffer membranes were formed. The prepared membranes were permeable to water vapors depending upon the cross-link density. The in vitro drug diffusion through excised rat abdominal skin depends on the cross-link density and polymer concentration. The primary skin irritation study indicated that the prepared membranes were less irritant and safe for drug delivery across the skin. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
