Development and Characterization of Sodium Alginate-Hydroxypropyl Methylcellulose-Polyester Multilayered Hydrogel Membranes for Drug Delivery through Skin.
Saved in:
| Title: | Development and Characterization of Sodium Alginate-Hydroxypropyl Methylcellulose-Polyester Multilayered Hydrogel Membranes for Drug Delivery through Skin. |
|---|---|
| Authors: | Kulkarni, Raghavendra V.1, Wagh, Yogesh J.1, Setty, C. Mallikarjun2, Sa, Biswanath3 |
| Source: | Polymer-Plastics Technology & Engineering. Mar2011, Vol. 50 Issue 5, p490-497. 8p. 1 Black and White Photograph, 1 Diagram, 2 Charts, 7 Graphs. |
| Subjects: | Sodium alginate, Cellulose, Polyesters, Artificial membranes, Drug delivery systems, Skin, Diethylamine, Anti-inflammatory agents, Permeability |
| Abstract: | The multi-layered hydrogel membranes of sodium alginate-hydroxypropyl methylcellulose-polyester were developed for controlled delivery of anti-inflammatory drug, diclofenac diethylamine through intact skin. The XRD studies indicated the amorphous dispersion of drug in the membranes. DSC analysis suggested that as cross-linking increases, the stiffer membranes were formed. The prepared membranes were permeable to water vapors depending upon the cross-link density. The in vitro drug diffusion through excised rat abdominal skin depends on the cross-link density and polymer concentration. The primary skin irritation study indicated that the prepared membranes were less irritant and safe for drug delivery across the skin. [ABSTRACT FROM AUTHOR] |
| Copyright of Polymer-Plastics Technology & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: egs DbLabel: Engineering Source An: 59792999 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Development and Characterization of Sodium Alginate-Hydroxypropyl Methylcellulose-Polyester Multilayered Hydrogel Membranes for Drug Delivery through Skin. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kulkarni%2C+Raghavendra+V%2E%22">Kulkarni, Raghavendra V.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Wagh%2C+Yogesh+J%2E%22">Wagh, Yogesh J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Setty%2C+C%2E+Mallikarjun%22">Setty, C. Mallikarjun</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Sa%2C+Biswanath%22">Sa, Biswanath</searchLink><relatesTo>3</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Polymer-Plastics+Technology+%26+Engineering%22">Polymer-Plastics Technology & Engineering</searchLink>. Mar2011, Vol. 50 Issue 5, p490-497. 8p. 1 Black and White Photograph, 1 Diagram, 2 Charts, 7 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Sodium+alginate%22">Sodium alginate</searchLink><br /><searchLink fieldCode="DE" term="%22Cellulose%22">Cellulose</searchLink><br /><searchLink fieldCode="DE" term="%22Polyesters%22">Polyesters</searchLink><br /><searchLink fieldCode="DE" term="%22Artificial+membranes%22">Artificial membranes</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Skin%22">Skin</searchLink><br /><searchLink fieldCode="DE" term="%22Diethylamine%22">Diethylamine</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-inflammatory+agents%22">Anti-inflammatory agents</searchLink><br /><searchLink fieldCode="DE" term="%22Permeability%22">Permeability</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The multi-layered hydrogel membranes of sodium alginate-hydroxypropyl methylcellulose-polyester were developed for controlled delivery of anti-inflammatory drug, diclofenac diethylamine through intact skin. The XRD studies indicated the amorphous dispersion of drug in the membranes. DSC analysis suggested that as cross-linking increases, the stiffer membranes were formed. The prepared membranes were permeable to water vapors depending upon the cross-link density. The in vitro drug diffusion through excised rat abdominal skin depends on the cross-link density and polymer concentration. The primary skin irritation study indicated that the prepared membranes were less irritant and safe for drug delivery across the skin. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Polymer-Plastics Technology & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=59792999 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/03602559.2010.543244 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 490 Subjects: – SubjectFull: Sodium alginate Type: general – SubjectFull: Cellulose Type: general – SubjectFull: Polyesters Type: general – SubjectFull: Artificial membranes Type: general – SubjectFull: Drug delivery systems Type: general – SubjectFull: Skin Type: general – SubjectFull: Diethylamine Type: general – SubjectFull: Anti-inflammatory agents Type: general – SubjectFull: Permeability Type: general Titles: – TitleFull: Development and Characterization of Sodium Alginate-Hydroxypropyl Methylcellulose-Polyester Multilayered Hydrogel Membranes for Drug Delivery through Skin. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kulkarni, Raghavendra V. – PersonEntity: Name: NameFull: Wagh, Yogesh J. – PersonEntity: Name: NameFull: Setty, C. Mallikarjun – PersonEntity: Name: NameFull: Sa, Biswanath IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 03 Text: Mar2011 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 03602559 Numbering: – Type: volume Value: 50 – Type: issue Value: 5 Titles: – TitleFull: Polymer-Plastics Technology & Engineering Type: main |
| ResultId | 1 |
