Correlation Between Local Hemodynamics and Lesion Distribution in a Novel Aortic Regurgitation Murine Model of Atherosclerosis.
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| Title: | Correlation Between Local Hemodynamics and Lesion Distribution in a Novel Aortic Regurgitation Murine Model of Atherosclerosis. |
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| Authors: | Hoi, Yiemeng1, Zhou, Yu-Qing2, Zhang, Xiaoli, Henkelman, R., Steinman, David1 steinman@mie.utoronto.ca |
| Source: | Annals of Biomedical Engineering. May2011, Vol. 39 Issue 5, p1414-1422. 9p. 2 Color Photographs, 3 Diagrams, 1 Graph. |
| Subjects: | Statistical correlation, Hemodynamics, Aortic valve insufficiency, Laboratory mice, Atherosclerosis, Fluid dynamics, Doppler effect |
| Abstract: | Following surgical induction of aortic valve regurgitation (AR), extensive atherosclerotic plaque development along the descending thoracic and abdominal aorta of Ldlr mice has been reported, with distinct spatial distributions suggestive of a strong local hemodynamic influence. The objective of this study was to test, using image-based computational fluid dynamics (CFD), whether this is indeed the case. The lumen geometry was reconstructed from micro-CT scanning of a control Ldlr mouse, and CFD simulations were carried out for both AR and control flow conditions derived from Doppler ultrasound measurements and literature data. Maps of time-averaged wall shear stress magnitude (TAWSS), oscillatory shear index (OSI) and relative residence time (RRT) were compared against the spatial distributions of plaque stained with oil red O, previously acquired in a group of AR and control mice. Maps of OSI and RRT were found to be consistent with plaque distributions in the AR mice and the absence of plaque in the control mice. TAWSS was uniformly lower under control vs. AR flow conditions, suggesting that levels (>100 dyn/cm) exceeded those required to alone induce a pro-atherogenic response. Simulations of a straightened CFD model confirmed the importance of anatomical curvature for explaining the spatial distribution of lesions in the AR mice. In summary, oscillatory and retrograde flow induced in the AR mice, without concomitant low shear, may exacerbate or accelerate lesion formation, but the distinct anatomical curvature of the mouse aorta is responsible for the spatial distribution of lesions. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 59809450 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Correlation Between Local Hemodynamics and Lesion Distribution in a Novel Aortic Regurgitation Murine Model of Atherosclerosis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hoi%2C+Yiemeng%22">Hoi, Yiemeng</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhou%2C+Yu-Qing%22">Zhou, Yu-Qing</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Xiaoli%22">Zhang, Xiaoli</searchLink><br /><searchLink fieldCode="AR" term="%22Henkelman%2C+R%2E%22">Henkelman, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Steinman%2C+David%22">Steinman, David</searchLink><relatesTo>1</relatesTo><i> steinman@mie.utoronto.ca</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. May2011, Vol. 39 Issue 5, p1414-1422. 9p. 2 Color Photographs, 3 Diagrams, 1 Graph. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Statistical+correlation%22">Statistical correlation</searchLink><br /><searchLink fieldCode="DE" term="%22Hemodynamics%22">Hemodynamics</searchLink><br /><searchLink fieldCode="DE" term="%22Aortic+valve+insufficiency%22">Aortic valve insufficiency</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink><br /><searchLink fieldCode="DE" term="%22Atherosclerosis%22">Atherosclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Fluid+dynamics%22">Fluid dynamics</searchLink><br /><searchLink fieldCode="DE" term="%22Doppler+effect%22">Doppler effect</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Following surgical induction of aortic valve regurgitation (AR), extensive atherosclerotic plaque development along the descending thoracic and abdominal aorta of Ldlr mice has been reported, with distinct spatial distributions suggestive of a strong local hemodynamic influence. The objective of this study was to test, using image-based computational fluid dynamics (CFD), whether this is indeed the case. The lumen geometry was reconstructed from micro-CT scanning of a control Ldlr mouse, and CFD simulations were carried out for both AR and control flow conditions derived from Doppler ultrasound measurements and literature data. Maps of time-averaged wall shear stress magnitude (TAWSS), oscillatory shear index (OSI) and relative residence time (RRT) were compared against the spatial distributions of plaque stained with oil red O, previously acquired in a group of AR and control mice. Maps of OSI and RRT were found to be consistent with plaque distributions in the AR mice and the absence of plaque in the control mice. TAWSS was uniformly lower under control vs. AR flow conditions, suggesting that levels (>100 dyn/cm) exceeded those required to alone induce a pro-atherogenic response. Simulations of a straightened CFD model confirmed the importance of anatomical curvature for explaining the spatial distribution of lesions in the AR mice. In summary, oscillatory and retrograde flow induced in the AR mice, without concomitant low shear, may exacerbate or accelerate lesion formation, but the distinct anatomical curvature of the mouse aorta is responsible for the spatial distribution of lesions. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10439-011-0255-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1414 Subjects: – SubjectFull: Statistical correlation Type: general – SubjectFull: Hemodynamics Type: general – SubjectFull: Aortic valve insufficiency Type: general – SubjectFull: Laboratory mice Type: general – SubjectFull: Atherosclerosis Type: general – SubjectFull: Fluid dynamics Type: general – SubjectFull: Doppler effect Type: general Titles: – TitleFull: Correlation Between Local Hemodynamics and Lesion Distribution in a Novel Aortic Regurgitation Murine Model of Atherosclerosis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hoi, Yiemeng – PersonEntity: Name: NameFull: Zhou, Yu-Qing – PersonEntity: Name: NameFull: Zhang, Xiaoli – PersonEntity: Name: NameFull: Henkelman, R. – PersonEntity: Name: NameFull: Steinman, David IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2011 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 00906964 Numbering: – Type: volume Value: 39 – Type: issue Value: 5 Titles: – TitleFull: Annals of Biomedical Engineering Type: main |
| ResultId | 1 |
