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A new type of irreversibly reductively biodegradable hydrogel

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Title: A new type of irreversibly reductively biodegradable hydrogel
Authors: Vetrik, Miroslav vetrix@seznam.cz, Hruby, Martin1, Pradny, Martin1, Michalek, Jiri1
Source: Polymer Degradation & Stability. May2011, Vol. 96 Issue 5, p892-897. 6p.
Subjects: Biodegradable products, Hydrogels, Crosslinked polymers, Nicotinamide, Tissue engineering, Phosphates, Scission (Chemistry)
Abstract: Abstract: Reductively biodegradable hydrogels based on poly[N-(2-hydroxypropyl)methacrylamide] crosslinked with N-[3-(methacryloylamino)propyl] -6-{[5-({[3-(methacryloylamino)propyl]amino}carbonyl)-2-pyridyl]disulfanyl}nicotinamide intended for tissue engineering were synthesized and characterized. The rate of irreversible reductive degradation with thiol l-cysteine (a model of human body where several thiols are present in extracellular space) was studied using several l-cysteine concentrations. The mechanism of the irreversible reductive bond cleavage in the crosslinker structure was confirmed on a low-molecular-weight model. The hydrogel is stable during storage in phosphate buffered saline and is degraded relatively quickly in a concentration-dependent manner after addition of l-cysteine to the surrounding medium. [Copyright &y& Elsevier]
Copyright of Polymer Degradation & Stability is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 59814696
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: A new type of irreversibly reductively biodegradable hydrogel
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  Data: <searchLink fieldCode="AR" term="%22Vetrik%2C+Miroslav%22">Vetrik, Miroslav</searchLink><i> vetrix@seznam.cz</i><br /><searchLink fieldCode="AR" term="%22Hruby%2C+Martin%22">Hruby, Martin</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Pradny%2C+Martin%22">Pradny, Martin</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Michalek%2C+Jiri%22">Michalek, Jiri</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Polymer+Degradation+%26+Stability%22">Polymer Degradation & Stability</searchLink>. May2011, Vol. 96 Issue 5, p892-897. 6p.
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  Data: <searchLink fieldCode="DE" term="%22Biodegradable+products%22">Biodegradable products</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogels%22">Hydrogels</searchLink><br /><searchLink fieldCode="DE" term="%22Crosslinked+polymers%22">Crosslinked polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Nicotinamide%22">Nicotinamide</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+engineering%22">Tissue engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Phosphates%22">Phosphates</searchLink><br /><searchLink fieldCode="DE" term="%22Scission+%28Chemistry%29%22">Scission (Chemistry)</searchLink>
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  Data: Abstract: Reductively biodegradable hydrogels based on poly[N-(2-hydroxypropyl)methacrylamide] crosslinked with N-[3-(methacryloylamino)propyl] -6-{[5-({[3-(methacryloylamino)propyl]amino}carbonyl)-2-pyridyl]disulfanyl}nicotinamide intended for tissue engineering were synthesized and characterized. The rate of irreversible reductive degradation with thiol l-cysteine (a model of human body where several thiols are present in extracellular space) was studied using several l-cysteine concentrations. The mechanism of the irreversible reductive bond cleavage in the crosslinker structure was confirmed on a low-molecular-weight model. The hydrogel is stable during storage in phosphate buffered saline and is degraded relatively quickly in a concentration-dependent manner after addition of l-cysteine to the surrounding medium. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Polymer Degradation & Stability is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.polymdegradstab.2011.01.037
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      – Code: eng
        Text: English
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        PageCount: 6
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        Type: general
      – SubjectFull: Hydrogels
        Type: general
      – SubjectFull: Crosslinked polymers
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      – SubjectFull: Nicotinamide
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      – SubjectFull: Tissue engineering
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      – SubjectFull: Phosphates
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      – SubjectFull: Scission (Chemistry)
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      – TitleFull: A new type of irreversibly reductively biodegradable hydrogel
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            NameFull: Hruby, Martin
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            NameFull: Michalek, Jiri
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              M: 05
              Text: May2011
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