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Structural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system

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Title: Structural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system
Authors: Chorilli, M.1, Prestes, P.S.2, Rigon, R.B.2, Leonardi, G.R.2, Chiavacci, L.A.1, Sarmento, V.H.V.3, Oliveira, A.G.1 ans-gomes@hotmail.com, Scarpa, M.V.1
Source: Colloids & Surfaces B: Biointerfaces. Jul2011, Vol. 85 Issue 2, p182-188. 7p.
Subjects: Structural analysis (Science), Liquid crystals, Rheology, Drug lipophilicity, Cosmetics, X-ray scattering
Abstract: Abstract: Carrier systems for lipophilic drugs, such as the liquid crystalline systems (LCS) have been extensively studied to improve effect and selectivity. Retinyl palmitate (RP) is widely used in pharmaceutical and cosmetics products to improve the skin elasticity. The aim of this study was the development, characterization and the in vivo effectiveness of RP in non-ionic LCS structures. LCS containing polyether functional siloxane as oil phase, silicon glycol copolymer as surfactant and water in the ratio 30:10:60, with and without RP were studied. The results of the polarized light microscopy, small-angle X-ray scattering and rheology analysis indicated the presence of typical LCS structures with lamellar arrangement. Regardless of the presence of RP, the rheological studies showed the pseudo plastic behavior of the systems. However, highest hysteresis area was verified when comparing the system in the presence and in the absence of RP. Stability study SAXS monitored, carried out up to 30 days in various storage temperature conditions (25±2°C, 37±2°C and 5±2°C) demonstrated the great structural stability of the LCS systems. The in vivo effectiveness analysis suggests that the RP-loaded LCS provided a significant reduction of the orbicular wrinkles in human volunteers (P =0.048). [Copyright &y& Elsevier]
Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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PubType: Academic Journal
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  Data: <searchLink fieldCode="AR" term="%22Chorilli%2C+M%2E%22">Chorilli, M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Prestes%2C+P%2ES%2E%22">Prestes, P.S.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Rigon%2C+R%2EB%2E%22">Rigon, R.B.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Leonardi%2C+G%2ER%2E%22">Leonardi, G.R.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Chiavacci%2C+L%2EA%2E%22">Chiavacci, L.A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Sarmento%2C+V%2EH%2EV%2E%22">Sarmento, V.H.V.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Oliveira%2C+A%2EG%2E%22">Oliveira, A.G.</searchLink><relatesTo>1</relatesTo><i> ans-gomes@hotmail.com</i><br /><searchLink fieldCode="AR" term="%22Scarpa%2C+M%2EV%2E%22">Scarpa, M.V.</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Colloids+%26+Surfaces+B%3A+Biointerfaces%22">Colloids & Surfaces B: Biointerfaces</searchLink>. Jul2011, Vol. 85 Issue 2, p182-188. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Structural+analysis+%28Science%29%22">Structural analysis (Science)</searchLink><br /><searchLink fieldCode="DE" term="%22Liquid+crystals%22">Liquid crystals</searchLink><br /><searchLink fieldCode="DE" term="%22Rheology%22">Rheology</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+lipophilicity%22">Drug lipophilicity</searchLink><br /><searchLink fieldCode="DE" term="%22Cosmetics%22">Cosmetics</searchLink><br /><searchLink fieldCode="DE" term="%22X-ray+scattering%22">X-ray scattering</searchLink>
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  Data: Abstract: Carrier systems for lipophilic drugs, such as the liquid crystalline systems (LCS) have been extensively studied to improve effect and selectivity. Retinyl palmitate (RP) is widely used in pharmaceutical and cosmetics products to improve the skin elasticity. The aim of this study was the development, characterization and the in vivo effectiveness of RP in non-ionic LCS structures. LCS containing polyether functional siloxane as oil phase, silicon glycol copolymer as surfactant and water in the ratio 30:10:60, with and without RP were studied. The results of the polarized light microscopy, small-angle X-ray scattering and rheology analysis indicated the presence of typical LCS structures with lamellar arrangement. Regardless of the presence of RP, the rheological studies showed the pseudo plastic behavior of the systems. However, highest hysteresis area was verified when comparing the system in the presence and in the absence of RP. Stability study SAXS monitored, carried out up to 30 days in various storage temperature conditions (25±2°C, 37±2°C and 5±2°C) demonstrated the great structural stability of the LCS systems. The in vivo effectiveness analysis suggests that the RP-loaded LCS provided a significant reduction of the orbicular wrinkles in human volunteers (P =0.048). [Copyright &y& Elsevier]
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  Data: <i>Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Jul2011
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