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[177Lu]DOTA-anti-CD20: Labeling and pre-clinical studies

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Title: [177Lu]DOTA-anti-CD20: Labeling and pre-clinical studies
Authors: Audicio, Paola F.1 paudicio@cin.edu.uy, Castellano, Gustavo2 gcas@famaf.unc.edu.ar, Tassano, Marcos R.1, Rezzano, Maria E.1, Fernandez, Marcelo1, Riva, Eloisa3, Robles, Ana1, Cabral, Pablo1, Balter, Henia1, Oliver, Patricia1
Source: Applied Radiation & Isotopes. Jul2011, Vol. 69 Issue 7, p924-928. 5p.
Subjects: Rituximab, Radioimmunotherapy, Lymphomas, Monoclonal antibodies, Radiopharmaceuticals, Radioactive tracers, Monte Carlo method, Radiochemistry
Abstract: Abstract: Anti-CD20 (Rituximab®), a specific chimeric monoclonal antibody used in CD20-positive Non-Hodgkin''s Lymphoma, was conjugated to a bifunctional quelate (DOTA) and radiolabeled with 177Lu through a simple method. [177Lu]-DOTA-anti-CD20 was obtained with a radiochemical purity higher than 97%, and showed good chemical and biological stability, maintaining its biospecificity to CD20 antigens. Monte Carlo simulation showed high doses deposited on a spheroid tumor mass model. This method seems to be an appropriate alternative for the production of [177Lu]-DOTA-anti-CD20 as therapeutic radiopharmaceutical. [Copyright &y& Elsevier]
Copyright of Applied Radiation & Isotopes is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: [<superscript>177</superscript>Lu]DOTA-anti-CD20: Labeling and pre-clinical studies
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  Data: <searchLink fieldCode="JN" term="%22Applied+Radiation+%26+Isotopes%22">Applied Radiation & Isotopes</searchLink>. Jul2011, Vol. 69 Issue 7, p924-928. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Rituximab%22">Rituximab</searchLink><br /><searchLink fieldCode="DE" term="%22Radioimmunotherapy%22">Radioimmunotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Lymphomas%22">Lymphomas</searchLink><br /><searchLink fieldCode="DE" term="%22Monoclonal+antibodies%22">Monoclonal antibodies</searchLink><br /><searchLink fieldCode="DE" term="%22Radiopharmaceuticals%22">Radiopharmaceuticals</searchLink><br /><searchLink fieldCode="DE" term="%22Radioactive+tracers%22">Radioactive tracers</searchLink><br /><searchLink fieldCode="DE" term="%22Monte+Carlo+method%22">Monte Carlo method</searchLink><br /><searchLink fieldCode="DE" term="%22Radiochemistry%22">Radiochemistry</searchLink>
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  Data: Abstract: Anti-CD20 (Rituximab®), a specific chimeric monoclonal antibody used in CD20-positive Non-Hodgkin''s Lymphoma, was conjugated to a bifunctional quelate (DOTA) and radiolabeled with 177Lu through a simple method. [177Lu]-DOTA-anti-CD20 was obtained with a radiochemical purity higher than 97%, and showed good chemical and biological stability, maintaining its biospecificity to CD20 antigens. Monte Carlo simulation showed high doses deposited on a spheroid tumor mass model. This method seems to be an appropriate alternative for the production of [177Lu]-DOTA-anti-CD20 as therapeutic radiopharmaceutical. [Copyright &y& Elsevier]
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  Data: <i>Copyright of Applied Radiation & Isotopes is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.apradiso.2011.01.026
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        Text: English
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      – SubjectFull: Rituximab
        Type: general
      – SubjectFull: Radioimmunotherapy
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      – SubjectFull: Lymphomas
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      – SubjectFull: Monoclonal antibodies
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      – SubjectFull: Monte Carlo method
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      – SubjectFull: Radiochemistry
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      – TitleFull: [177Lu]DOTA-anti-CD20: Labeling and pre-clinical studies
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              Text: Jul2011
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