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Catalytic asymmetric hydrogenation to access spiroindane dimethyl acetic acid

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Title: Catalytic asymmetric hydrogenation to access spiroindane dimethyl acetic acid
Authors: He, Shuwen1 shuwen_he@merck.com, Shultz, C. Scott2, Lai, Zhong1, Eid, Ronsar2, Dobbelaar, Peter H.1, Ye, Zhixiong1, Nargund, Ravi P.1
Source: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jul2011, Vol. 52 Issue 28, p3621-3624. 4p.
Subjects: Asymmetry (Chemistry), Hydrogenation, Acetic acid, Enantiomers, Chirality, Phosphine, Ruthenium compounds, Acetone, Catalysis
Abstract: Abstract: Asymmetric hydrogenation of achiral spiroindene dimethyl acetic acid 2 with 4% of Ru(II)-Mandyphos in acetone produced (S)-spiroindane dimethyl acetic acid 1 in 86% isolated yield and 96.8:3.2 enantiomeric ratio. [Copyright &y& Elsevier]
Copyright of Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Abstract: Asymmetric hydrogenation of achiral spiroindene dimethyl acetic acid 2 with 4% of Ru(II)-Mandyphos in acetone produced (S)-spiroindane dimethyl acetic acid 1 in 86% isolated yield and 96.8:3.2 enantiomeric ratio. [Copyright &y& Elsevier]
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  Data: <i>Copyright of Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.tetlet.2011.05.029
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      – SubjectFull: Phosphine
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      – SubjectFull: Catalysis
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      – TitleFull: Catalytic asymmetric hydrogenation to access spiroindane dimethyl acetic acid
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              Text: Jul2011
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