Gynaecomastia linked to the intake of a herbal supplement fortified with diethylstilbestrol.
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| Title: | Gynaecomastia linked to the intake of a herbal supplement fortified with diethylstilbestrol. |
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| Authors: | Toorians, A.W.F.T.1 (AUTHOR), Bovee, T.F.H.2 (AUTHOR) toine.bovee@wur.nl, De Rooy, J.1 (AUTHOR), Stolker, L.A.A.M.2 (AUTHOR), Hoogenboom, R.L.A.P.2 (AUTHOR) |
| Source: | Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment. Jul2010, Vol. 27 Issue 7, p917-925. 9p. 1 Diagram, 1 Chart, 3 Graphs. |
| Abstract: | This study reports the findings of a supplement marketed on the Internet for prostate problems. The supplement was orally taken by a 60-year-old man with divergent hormonal levels and who was surgically treated for gynaecomastia: development of abnormally large mammary glands in males. The supplement showed a strong effect in a yeast oestrogen bioassay, expressing a yeast-enhanced green fluorescent protein (yEGFP) upon exposure to oestrogens. Using both nuclear magnetic resonance (NMR) and a gradient liquid chromatographic time-of-flight mass spectrometric (LC/TOF-MS) method, the response was shown to be caused by very high levels of diethylstilbestrol, known for causing gynaecomastia. The gynaecomastia was most probably caused by this orally taken 'natural' herbal supplement, as the patient's hormonal levels also returned to normal again when stopping the use of it. This case demonstrates that physicians need to be aware of the use of supplements with illegal components that may be responsible for unwanted side-effects. [ABSTRACT FROM AUTHOR] |
| Copyright of Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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