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PANcreatic-DERived factor: Novel hormone PANDERing to glucose regulation

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Title: PANcreatic-DERived factor: Novel hormone PANDERing to glucose regulation
Authors: Wilson, Camella G.1, Robert-Cooperman, Claudia E.2, Burkhardt, Brant R.2,3 bburkhardt@usf.edu
Source: FEBS Letters. Jul2011, Vol. 585 Issue 14, p2137-2143. 7p.
Subjects: Islands of Langerhans, Cytokines, Glucose, Gene expression, Apoptosis, Treatment of diabetes, Animal models in research
Abstract: Abstract: PANcreatic-DERived factor (PANDER, FAM3B) is a member of the FAM3 family of cytokine molecules that were initially described in 2002. PANDER expression is primarily localized to the endocrine pancreas and is secreted from both pancreatic α and β-cells. Initial characterization of PANDER revealed a potential role in pancreatic islet apoptosis. However, recent animal models have indicated PANDER functions as a hormone by regulating glucose levels via interaction with both the liver and the endocrine pancreas. An understanding of the function of PANDER can further the insight into the mechanisms of glucose regulation and potentially provide additional therapeutic targets for the treatment of diabetes. This review details the supporting data demonstrating PANDER has a biological function in glycemic regulation. [Copyright &y& Elsevier]
Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 62976648
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: PANcreatic-DERived factor: Novel hormone PANDERing to glucose regulation
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  Data: <searchLink fieldCode="AR" term="%22Wilson%2C+Camella+G%2E%22">Wilson, Camella G.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Robert-Cooperman%2C+Claudia+E%2E%22">Robert-Cooperman, Claudia E.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Burkhardt%2C+Brant+R%2E%22">Burkhardt, Brant R.</searchLink><relatesTo>2,3</relatesTo><i> bburkhardt@usf.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22FEBS+Letters%22">FEBS Letters</searchLink>. Jul2011, Vol. 585 Issue 14, p2137-2143. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Islands+of+Langerhans%22">Islands of Langerhans</searchLink><br /><searchLink fieldCode="DE" term="%22Cytokines%22">Cytokines</searchLink><br /><searchLink fieldCode="DE" term="%22Glucose%22">Glucose</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Apoptosis%22">Apoptosis</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+of+diabetes%22">Treatment of diabetes</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+models+in+research%22">Animal models in research</searchLink>
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  Data: Abstract: PANcreatic-DERived factor (PANDER, FAM3B) is a member of the FAM3 family of cytokine molecules that were initially described in 2002. PANDER expression is primarily localized to the endocrine pancreas and is secreted from both pancreatic α and β-cells. Initial characterization of PANDER revealed a potential role in pancreatic islet apoptosis. However, recent animal models have indicated PANDER functions as a hormone by regulating glucose levels via interaction with both the liver and the endocrine pancreas. An understanding of the function of PANDER can further the insight into the mechanisms of glucose regulation and potentially provide additional therapeutic targets for the treatment of diabetes. This review details the supporting data demonstrating PANDER has a biological function in glycemic regulation. [Copyright &y& Elsevier]
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  Data: <i>Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.febslet.2011.05.059
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      – Code: eng
        Text: English
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    Subjects:
      – SubjectFull: Islands of Langerhans
        Type: general
      – SubjectFull: Cytokines
        Type: general
      – SubjectFull: Glucose
        Type: general
      – SubjectFull: Gene expression
        Type: general
      – SubjectFull: Apoptosis
        Type: general
      – SubjectFull: Treatment of diabetes
        Type: general
      – SubjectFull: Animal models in research
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      – TitleFull: PANcreatic-DERived factor: Novel hormone PANDERing to glucose regulation
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              Text: Jul2011
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