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Nano-hydroxyapatite/chitosan sponge-like biocomposite for repairing of rat calvarial critical-sized bone defect.

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Title: Nano-hydroxyapatite/chitosan sponge-like biocomposite for repairing of rat calvarial critical-sized bone defect.
Authors: Xing Ma1, Yang Wang2, Hun Guo3, Jintang Wang4
Source: Journal of Bioactive & Compatible Polymers. Jul2011, Vol. 26 Issue 4, p335-346. 12p.
Subjects: Nanostructured materials, Hydroxyapatite, Chitosan, Biomedical materials, Composite materials, Laboratory rats, Bone abnormalities, Porous materials, Biosynthesis
Abstract: A three-dimensional porous nano-hydroxyapatite (nHA)/chitosan (CS) biocomposite was synthesized. The rod-like nHA grains of 15—30 × 5—10 nm in size were observed by TEM and confirmed by characteristic XRD patterns. The diameters of the interconnecting pores of the nHA/CS biocomposite, determined by SEM, were 120—300 μm. Standard critical-sized calvarial bone defect ( = 6.5 mm) was created in Sprague-Dawley (SD) rats. In group 1, nHA/CS was implanted and in group 2, no implant was made in the defect. After 1 week, the histological assessment of group 1 clearly showed that a large number of living cells were anchored in the pores of the nHA/CS implants. New bone formation, both at the edge and in the center of implants, was found as early as 2 weeks. Histological assays confirmed that the newly formed bone tissue was bioactive and neovascularized. After 5 weeks, the mineral content and volume of the newly formed bone tissue in the defects were significantly greater in group 1 than in group 2 (p < 0.01). These results indicate that implantation of the nHA/CS enhanced the repair of bone defect and confirm the potential of this biocomposite as a bioactive bone grafting substitute. [ABSTRACT FROM PUBLISHER]
Copyright of Journal of Bioactive & Compatible Polymers is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 63248925
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Nano-hydroxyapatite/chitosan sponge-like biocomposite for repairing of rat calvarial critical-sized bone defect.
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  Data: A three-dimensional porous nano-hydroxyapatite (nHA)/chitosan (CS) biocomposite was synthesized. The rod-like nHA grains of 15—30 &#215; 5—10 nm in size were observed by TEM and confirmed by characteristic XRD patterns. The diameters of the interconnecting pores of the nHA/CS biocomposite, determined by SEM, were 120—300 μm. Standard critical-sized calvarial bone defect ( = 6.5 mm) was created in Sprague-Dawley (SD) rats. In group 1, nHA/CS was implanted and in group 2, no implant was made in the defect. After 1 week, the histological assessment of group 1 clearly showed that a large number of living cells were anchored in the pores of the nHA/CS implants. New bone formation, both at the edge and in the center of implants, was found as early as 2 weeks. Histological assays confirmed that the newly formed bone tissue was bioactive and neovascularized. After 5 weeks, the mineral content and volume of the newly formed bone tissue in the defects were significantly greater in group 1 than in group 2 (p &lt; 0.01). These results indicate that implantation of the nHA/CS enhanced the repair of bone defect and confirm the potential of this biocomposite as a bioactive bone grafting substitute. [ABSTRACT FROM PUBLISHER]
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  Data: &lt;i&gt;Copyright of Journal of Bioactive &amp; Compatible Polymers is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1177/0883911511407402
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 335
    Subjects:
      – SubjectFull: Nanostructured materials
        Type: general
      – SubjectFull: Hydroxyapatite
        Type: general
      – SubjectFull: Chitosan
        Type: general
      – SubjectFull: Biomedical materials
        Type: general
      – SubjectFull: Composite materials
        Type: general
      – SubjectFull: Laboratory rats
        Type: general
      – SubjectFull: Bone abnormalities
        Type: general
      – SubjectFull: Porous materials
        Type: general
      – SubjectFull: Biosynthesis
        Type: general
    Titles:
      – TitleFull: Nano-hydroxyapatite/chitosan sponge-like biocomposite for repairing of rat calvarial critical-sized bone defect.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Xing Ma
      – PersonEntity:
          Name:
            NameFull: Yang Wang
      – PersonEntity:
          Name:
            NameFull: Hun Guo
      – PersonEntity:
          Name:
            NameFull: Jintang Wang
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: Jul2011
              Type: published
              Y: 2011
          Identifiers:
            – Type: issn-print
              Value: 08839115
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            – Type: volume
              Value: 26
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Journal of Bioactive & Compatible Polymers
              Type: main
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