In vivo myocardial infarct area at risk assessment in the rat using manganese enhanced magnetic resonance imaging (MEMRI) at 1.5T.
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| Title: | In vivo myocardial infarct area at risk assessment in the rat using manganese enhanced magnetic resonance imaging (MEMRI) at 1.5T. |
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| Authors: | Daire, J.L.1, Hyacinthe, J.N.1, Tatar, I.1, Montet-Abou, K.1, Ivancevic, M.K.1, Masterson, K.1,2, Jorge-Costa, M.2, Morel, D.R.2, Vallée, J.P.1 |
| Source: | Magnetic Resonance in Medicine. Jun2008, Vol. 59 Issue 6, p1422-1430. 9p. |
| Abstract: | The aim of this study was to measure the myocardial area at risk in rat, using MRI and manganese injection during a coronary occlusion/reperfusion model at 1.5T. A sequential protocol with occlusion and MnCl2 injection immediately followed by MRI was used with the assumption that MnCl2-induced contrast persistence is enough to accurately image the area at risk 90 min after occlusion. A total of 15 adult rats underwent a single 30-min episode of coronary occlusion followed by reperfusion. MnCl2 was injected (25 μmol/kg) at the beginning of the occlusion for 11 rats (group 1) and 6 h after reperfusion for four animals (group 2). A deficit of signal enhancement was observed in all rats. Hypoenhancement area in group 1 was correlated to the area at risk delineated by methylene blue (r = 0.96, P < 0.0001) whereas in group 2 it was correlated to the infarct area given by triphenyltetrazolium chloride (TTC) solution (r = 0.98, P = 0.003). The area at risk size was significantly correlated with left ventricle ejection fraction (LVEF), end-systolic volume and anterolateral wall thickening. This work demonstrates that hypoenhanced zone obtained after manganese injection during occlusion represents the area at risk and not only the infarct zone. Magn Reson Med 59:1422-1430, 2008. © 2008 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 63336680 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: In vivo myocardial infarct area at risk assessment in the rat using manganese enhanced magnetic resonance imaging (MEMRI) at 1.5T. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Daire%2C+J%2EL%2E%22">Daire, J.L.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hyacinthe%2C+J%2EN%2E%22">Hyacinthe, J.N.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Tatar%2C+I%2E%22">Tatar, I.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Montet-Abou%2C+K%2E%22">Montet-Abou, K.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ivancevic%2C+M%2EK%2E%22">Ivancevic, M.K.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Masterson%2C+K%2E%22">Masterson, K.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Jorge-Costa%2C+M%2E%22">Jorge-Costa, M.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Morel%2C+D%2ER%2E%22">Morel, D.R.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Vallée%2C+J%2EP%2E%22">Vallée, J.P.</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Jun2008, Vol. 59 Issue 6, p1422-1430. 9p. – Name: Abstract Label: Abstract Group: Ab Data: The aim of this study was to measure the myocardial area at risk in rat, using MRI and manganese injection during a coronary occlusion/reperfusion model at 1.5T. A sequential protocol with occlusion and MnCl2 injection immediately followed by MRI was used with the assumption that MnCl2-induced contrast persistence is enough to accurately image the area at risk 90 min after occlusion. A total of 15 adult rats underwent a single 30-min episode of coronary occlusion followed by reperfusion. MnCl2 was injected (25 μmol/kg) at the beginning of the occlusion for 11 rats (group 1) and 6 h after reperfusion for four animals (group 2). A deficit of signal enhancement was observed in all rats. Hypoenhancement area in group 1 was correlated to the area at risk delineated by methylene blue (r = 0.96, P < 0.0001) whereas in group 2 it was correlated to the infarct area given by triphenyltetrazolium chloride (TTC) solution (r = 0.98, P = 0.003). The area at risk size was significantly correlated with left ventricle ejection fraction (LVEF), end-systolic volume and anterolateral wall thickening. This work demonstrates that hypoenhanced zone obtained after manganese injection during occlusion represents the area at risk and not only the infarct zone. Magn Reson Med 59:1422-1430, 2008. © 2008 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.21493 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1422 Titles: – TitleFull: In vivo myocardial infarct area at risk assessment in the rat using manganese enhanced magnetic resonance imaging (MEMRI) at 1.5T. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Daire, J.L. – PersonEntity: Name: NameFull: Hyacinthe, J.N. – PersonEntity: Name: NameFull: Tatar, I. – PersonEntity: Name: NameFull: Montet-Abou, K. – PersonEntity: Name: NameFull: Ivancevic, M.K. – PersonEntity: Name: NameFull: Masterson, K. – PersonEntity: Name: NameFull: Jorge-Costa, M. – PersonEntity: Name: NameFull: Morel, D.R. – PersonEntity: Name: NameFull: Vallée, J.P. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 59 – Type: issue Value: 6 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
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