Characterization of 1H NMR signal in human cortical bone for magnetic resonance imaging.
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| Title: | Characterization of 1H NMR signal in human cortical bone for magnetic resonance imaging. |
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| Authors: | Horch, R. Adam1,2, Nyman, Jeffry S.3,4, Gochberg, Daniel F.2,5, Dortch, Richard D.2,5, Does, Mark D.1,2,5,6 |
| Source: | Magnetic Resonance in Medicine. Sep2010, Vol. 64 Issue 3, p680-687. 8p. |
| Abstract: | Recent advancements in MRI have enabled clinical imaging of human cortical bone, providing a potentially powerful new means for assessing bone health with molecular-scale sensitivities unavailable to conventional X-ray-based diagnostics. In human cortical bone, MRI is sensitive to populations of protons (1H) partitioned among water and protein sources, which may be differentiated according to intrinsic NMR properties such as chemical shift and transverse and longitudinal relaxation rates. Herein, these NMR properties were assessed in human cortical bone donors from a broad age range, and four distinct 1H populations were consistently identified and attributed to five microanatomical sources. These findings show that modern human cortical bone MRI contrast will be dominated by collagen-bound water, which can also be exploited to study human cortical bone collagen via magnetization transfer. Magn Reson Med, 2010. © 2010 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 63337427 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.22459 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 680 Titles: – TitleFull: Characterization of 1H NMR signal in human cortical bone for magnetic resonance imaging. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Horch, R. Adam – PersonEntity: Name: NameFull: Nyman, Jeffry S. – PersonEntity: Name: NameFull: Gochberg, Daniel F. – PersonEntity: Name: NameFull: Dortch, Richard D. – PersonEntity: Name: NameFull: Does, Mark D. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 64 – Type: issue Value: 3 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
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