Bibliographic Details
| Title: |
Strategies for the separation of polyelectrolytes based on non-linear dynamics and entropic ratchets in a simple microfluidic device. |
| Authors: |
Tessier, F., Slater, G.W. |
| Source: |
Applied Physics A: Materials Science & Processing. 2002, Vol. 75 Issue 2, p285. 7p. 3 Graphs. |
| Subjects: |
Electrophoresis, Polyelectrolytes, Biomechanics |
| Abstract: |
We perform Monte Carlo simulations of an existing electrophoretic microchannel device used for the size separation of large DNA fragments. This device is normally operated with a constant (dc) driving field. In contrast, we consider the case of a varying (ac) driving field, in the zero-frequency limit. We find that a time-asymmetric pulse can yield interesting migration regimes, in particular bidirectional transport for different molecular sizes. We also study a spatially asymmetric version of the device and show that it can rectify unbiased but non-equilibrium molecular motion, in agreement with previous predictions for entropic ratchets. Finally, at finite frequency we uncover a resonance for the molecular velocity in the channel which could lead to improved performance. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
