Strategies for the separation of polyelectrolytes based on non-linear dynamics and entropic ratchets in a simple microfluidic device.
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| Title: | Strategies for the separation of polyelectrolytes based on non-linear dynamics and entropic ratchets in a simple microfluidic device. |
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| Authors: | Tessier, F., Slater, G.W. |
| Source: | Applied Physics A: Materials Science & Processing. 2002, Vol. 75 Issue 2, p285. 7p. 3 Graphs. |
| Subjects: | Electrophoresis, Polyelectrolytes, Biomechanics |
| Abstract: | We perform Monte Carlo simulations of an existing electrophoretic microchannel device used for the size separation of large DNA fragments. This device is normally operated with a constant (dc) driving field. In contrast, we consider the case of a varying (ac) driving field, in the zero-frequency limit. We find that a time-asymmetric pulse can yield interesting migration regimes, in particular bidirectional transport for different molecular sizes. We also study a spatially asymmetric version of the device and show that it can rectify unbiased but non-equilibrium molecular motion, in agreement with previous predictions for entropic ratchets. Finally, at finite frequency we uncover a resonance for the molecular velocity in the channel which could lead to improved performance. [ABSTRACT FROM AUTHOR] |
| Copyright of Applied Physics A: Materials Science & Processing is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Strategies for the separation of polyelectrolytes based on non-linear dynamics and entropic ratchets in a simple microfluidic device. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Tessier%2C+F%2E%22">Tessier, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Slater%2C+G%2EW%2E%22">Slater, G.W.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Applied+Physics+A%3A+Materials+Science+%26+Processing%22">Applied Physics A: Materials Science & Processing</searchLink>. 2002, Vol. 75 Issue 2, p285. 7p. 3 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Electrophoresis%22">Electrophoresis</searchLink><br /><searchLink fieldCode="DE" term="%22Polyelectrolytes%22">Polyelectrolytes</searchLink><br /><searchLink fieldCode="DE" term="%22Biomechanics%22">Biomechanics</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: We perform Monte Carlo simulations of an existing electrophoretic microchannel device used for the size separation of large DNA fragments. This device is normally operated with a constant (dc) driving field. In contrast, we consider the case of a varying (ac) driving field, in the zero-frequency limit. We find that a time-asymmetric pulse can yield interesting migration regimes, in particular bidirectional transport for different molecular sizes. We also study a spatially asymmetric version of the device and show that it can rectify unbiased but non-equilibrium molecular motion, in agreement with previous predictions for entropic ratchets. Finally, at finite frequency we uncover a resonance for the molecular velocity in the channel which could lead to improved performance. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Applied Physics A: Materials Science & Processing is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s003390201337 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 285 Subjects: – SubjectFull: Electrophoresis Type: general – SubjectFull: Polyelectrolytes Type: general – SubjectFull: Biomechanics Type: general Titles: – TitleFull: Strategies for the separation of polyelectrolytes based on non-linear dynamics and entropic ratchets in a simple microfluidic device. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Tessier, F. – PersonEntity: Name: NameFull: Slater, G.W. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: 2002 Type: published Y: 2002 Identifiers: – Type: issn-print Value: 09478396 Numbering: – Type: volume Value: 75 – Type: issue Value: 2 Titles: – TitleFull: Applied Physics A: Materials Science & Processing Type: main |
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