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Infrared (810 nm) Low-level Laser Therapy in Rat Achilles Tendinitis: A Consistent Alternative to Drugs.

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Title: Infrared (810 nm) Low-level Laser Therapy in Rat Achilles Tendinitis: A Consistent Alternative to Drugs.
Authors: Marcos, Rodrigo Labat1, Leal Junior, Ernesto Cesar Pinto2, de Moura Messias, Felipe2, Catelli de Carvalho, Maria Helena3, Pallotta, Rodney Capp1, Frigo, Lúcio4, dos Santos, Rosângela Aparecida3, Ramos, Luciano1, Teixeira, Simone1, Bjordal, Jan Magnus5, Lopes-Martins, Rodrigo Álvaro Brandão1,2
Source: Photochemistry & Photobiology. Nov2011, Vol. 87 Issue 6, p1447-1452. 6p. 4 Graphs.
Subjects: Infrared radiation, Laser therapy, Laboratory rats, Achilles tendinitis, Alternative medicine, Nonsteroidal anti-inflammatory agents, Pain management, Cyclooxygenases, Gene expression, Cytokines, Collagenases, Therapeutics
Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used and can reduce musculoskeletal pain in spite of the cost of adverse reactions like gastrointestinal ulcers or cardiovascular events. The current study investigates if a safer treatment such as low-level laser therapy (LLLT) could reduce tendinitis inflammation, and whether a possible pathway could be through inhibition of either of the two-cyclooxygenase (COX) isoforms in inflammation. Wistar rats (six animals per group) were injected with saline (control) or collagenase in their Achilles tendons. Then, we treated them with three different doses of IR LLLT (810 nm; 100 mW; 10 s, 30 s and 60 s; 3.57 W cm−2; 1 J, 3 J, 6 J) at the sites of the injections, or intramuscular diclofenac, a nonselective COX inhibitor/NSAID. We found that LLLT dose of 3 J significantly reduced inflammation through less COX-2-derived gene expression and PGE2 production, and less edema formation compared to nonirradiated controls. Diclofenac controls exhibited significantly lower PGE2 cytokine levels at 6 h than collagenase control, but COX isoform 1-derived gene expression and cytokine PGE2 levels were not affected by treatments. As LLLT seems to act on inflammation through a selective inhibition of the COX-2 isoform in collagenase-induced tendinitis, LLLT may have potential to become a new and safer nondrug alternative to coxibs. [ABSTRACT FROM AUTHOR]
Copyright of Photochemistry & Photobiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Infrared (810 nm) Low-level Laser Therapy in Rat Achilles Tendinitis: A Consistent Alternative to Drugs.
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  Data: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used and can reduce musculoskeletal pain in spite of the cost of adverse reactions like gastrointestinal ulcers or cardiovascular events. The current study investigates if a safer treatment such as low-level laser therapy (LLLT) could reduce tendinitis inflammation, and whether a possible pathway could be through inhibition of either of the two-cyclooxygenase (COX) isoforms in inflammation. Wistar rats (six animals per group) were injected with saline (control) or collagenase in their Achilles tendons. Then, we treated them with three different doses of IR LLLT (810 nm; 100 mW; 10 s, 30 s and 60 s; 3.57 W cm−2; 1 J, 3 J, 6 J) at the sites of the injections, or intramuscular diclofenac, a nonselective COX inhibitor/NSAID. We found that LLLT dose of 3 J significantly reduced inflammation through less COX-2-derived gene expression and PGE2 production, and less edema formation compared to nonirradiated controls. Diclofenac controls exhibited significantly lower PGE2 cytokine levels at 6 h than collagenase control, but COX isoform 1-derived gene expression and cytokine PGE2 levels were not affected by treatments. As LLLT seems to act on inflammation through a selective inhibition of the COX-2 isoform in collagenase-induced tendinitis, LLLT may have potential to become a new and safer nondrug alternative to coxibs. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Photochemistry & Photobiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1111/j.1751-1097.2011.00999.x
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      – Code: eng
        Text: English
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        PageCount: 6
        StartPage: 1447
    Subjects:
      – SubjectFull: Infrared radiation
        Type: general
      – SubjectFull: Laser therapy
        Type: general
      – SubjectFull: Laboratory rats
        Type: general
      – SubjectFull: Achilles tendinitis
        Type: general
      – SubjectFull: Alternative medicine
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      – SubjectFull: Nonsteroidal anti-inflammatory agents
        Type: general
      – SubjectFull: Pain management
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      – SubjectFull: Cyclooxygenases
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      – SubjectFull: Gene expression
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      – SubjectFull: Cytokines
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      – SubjectFull: Collagenases
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      – SubjectFull: Therapeutics
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    Titles:
      – TitleFull: Infrared (810 nm) Low-level Laser Therapy in Rat Achilles Tendinitis: A Consistent Alternative to Drugs.
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              Text: Nov2011
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