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Lutetium-177 and iodine-131 loaded chelating polymer microparticles intended for radioembolization of liver malignancies

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Title: Lutetium-177 and iodine-131 loaded chelating polymer microparticles intended for radioembolization of liver malignancies
Authors: Hruby, Martin1 mhruby@centrum.cz, Skodova, Michaela1, Mackova, Hana1, Skopal, Jan1, Tomes, Marek2, Kropacek, Martin2, Zimova, Jana2, Kucka, Jan1
Source: Reactive & Functional Polymers. Dec2011, Vol. 71 Issue 12, p1155-1159. 5p.
Subjects: Lutetium, Iodine, Chelates, Radioembolization, Liver diseases, Acetic acid, Laboratory rats, Blood plasma
Abstract: Abstract: We describe the synthesis, characterization and radiochemical studies on macroporous chelating polymer beads as carriers of beta-emitters lutetium-177 and iodine-131 intended for radioembolization of liver tumors. The starting poly(glycidyl methacrylate-co-ethylene dimethacrylate) (bead size 20–40μ) was reacted with ammonia or methylamine to introduce primary and secondary amino groups, respectively. The primary amino groups containing polymer was used for the attachment of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) moieties, while quinoline-8-ol or 8-hydroxyquinoline-5-sulfonic acid moieties, respectively, were introduced onto the secondary amino groups containing polymer. All the polymers were labeled quantitatively by lutetium-177 in ammonium acetate buffer, DOTA containing beads however required heating to 80°C while the quinoline-8-ol or 8-hydroxyquinoline-5-sulfonic acid moieties containing polymers were quantitatively radiolabeled within 1h at room temperature. The quinoline-8-ol groups containing polymer was radioiodinated in 95% yield by a chloramine method. Both lutetium-177 and iodine-131 radiolabels were stable in an in vitro study in rat blood plasma. Quinoline-8-ol or 8-hydroxyquinoline-5-sulfonic acid moieties are thus more suitable for the radiolabeling of macroporous beads with lutetium-177 for radioembolization purposes than well-established DOTA moieties and in addition, quinoline-8-ol also allows radiolabeling with iodine-131. [Copyright &y& Elsevier]
Copyright of Reactive & Functional Polymers is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 66768624
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Lutetium-177 and iodine-131 loaded chelating polymer microparticles intended for radioembolization of liver malignancies
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  Data: <searchLink fieldCode="AR" term="%22Hruby%2C+Martin%22">Hruby, Martin</searchLink><relatesTo>1</relatesTo><i> mhruby@centrum.cz</i><br /><searchLink fieldCode="AR" term="%22Skodova%2C+Michaela%22">Skodova, Michaela</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Mackova%2C+Hana%22">Mackova, Hana</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Skopal%2C+Jan%22">Skopal, Jan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Tomes%2C+Marek%22">Tomes, Marek</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Kropacek%2C+Martin%22">Kropacek, Martin</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Zimova%2C+Jana%22">Zimova, Jana</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Kucka%2C+Jan%22">Kucka, Jan</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Reactive+%26+Functional+Polymers%22">Reactive & Functional Polymers</searchLink>. Dec2011, Vol. 71 Issue 12, p1155-1159. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Lutetium%22">Lutetium</searchLink><br /><searchLink fieldCode="DE" term="%22Iodine%22">Iodine</searchLink><br /><searchLink fieldCode="DE" term="%22Chelates%22">Chelates</searchLink><br /><searchLink fieldCode="DE" term="%22Radioembolization%22">Radioembolization</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+diseases%22">Liver diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Acetic+acid%22">Acetic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+plasma%22">Blood plasma</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Abstract: We describe the synthesis, characterization and radiochemical studies on macroporous chelating polymer beads as carriers of beta-emitters lutetium-177 and iodine-131 intended for radioembolization of liver tumors. The starting poly(glycidyl methacrylate-co-ethylene dimethacrylate) (bead size 20–40μ) was reacted with ammonia or methylamine to introduce primary and secondary amino groups, respectively. The primary amino groups containing polymer was used for the attachment of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) moieties, while quinoline-8-ol or 8-hydroxyquinoline-5-sulfonic acid moieties, respectively, were introduced onto the secondary amino groups containing polymer. All the polymers were labeled quantitatively by lutetium-177 in ammonium acetate buffer, DOTA containing beads however required heating to 80°C while the quinoline-8-ol or 8-hydroxyquinoline-5-sulfonic acid moieties containing polymers were quantitatively radiolabeled within 1h at room temperature. The quinoline-8-ol groups containing polymer was radioiodinated in 95% yield by a chloramine method. Both lutetium-177 and iodine-131 radiolabels were stable in an in vitro study in rat blood plasma. Quinoline-8-ol or 8-hydroxyquinoline-5-sulfonic acid moieties are thus more suitable for the radiolabeling of macroporous beads with lutetium-177 for radioembolization purposes than well-established DOTA moieties and in addition, quinoline-8-ol also allows radiolabeling with iodine-131. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Reactive & Functional Polymers is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
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      – Type: doi
        Value: 10.1016/j.reactfunctpolym.2011.09.003
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      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 5
        StartPage: 1155
    Subjects:
      – SubjectFull: Lutetium
        Type: general
      – SubjectFull: Iodine
        Type: general
      – SubjectFull: Chelates
        Type: general
      – SubjectFull: Radioembolization
        Type: general
      – SubjectFull: Liver diseases
        Type: general
      – SubjectFull: Acetic acid
        Type: general
      – SubjectFull: Laboratory rats
        Type: general
      – SubjectFull: Blood plasma
        Type: general
    Titles:
      – TitleFull: Lutetium-177 and iodine-131 loaded chelating polymer microparticles intended for radioembolization of liver malignancies
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            NameFull: Skopal, Jan
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            – D: 01
              M: 12
              Text: Dec2011
              Type: published
              Y: 2011
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