Nonexponential T2* decay in white matter.
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| Title: | Nonexponential T |
|---|---|
| Authors: | van Gelderen, Peter1, de Zwart, Jacco A.1, Lee, Jongho1,2, Sati, Pascal3, Reich, Daniel S.3, Duyn, Jeff H.1 |
| Source: | Magnetic Resonance in Medicine. Jan2012, Vol. 67 Issue 1, p110-117. 8p. |
| Abstract: | Visualizing myelin in human brain may help the study of diseases such as multiple sclerosis. Previous studies based on T1 and T2 relaxation contrast have suggested the presence of a distinct water pool that may report directly on local myelin content. Recent work indicates that T2* contrast may offer particular advantages over T1 and T2 contrast, especially at high field. However, the complex mechanism underlying T2* relaxation may render interpretation difficult. To address this issue, T2* relaxation behavior in human brain was studied at 3 and 7 T. Multiple gradient echoes covering most of the decay curve were analyzed for deviations from mono-exponential behavior. The data confirm the previous finding of a distinct rapidly relaxing signal component ( T2* ∼ 6 ms), tentatively attributed to myelin water. However, in extension to previous findings, this rapidly relaxing component displayed a substantial resonance frequency shift, reaching 36 Hz in the corpus callosum at 7 T. The component's fractional amplitude and frequency shift appeared to depend on both field strength and fiber orientation, consistent with a mechanism originating from magnetic susceptibility effects. The findings suggest that T2* contrast at high field may be uniquely sensitive to tissue myelin content and that proper interpretation will require modeling of susceptibility-induced resonance frequency shifts. Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 69947801 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Nonexponential T<subscript>2</subscript>* decay in white matter. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22van+Gelderen%2C+Peter%22">van Gelderen, Peter</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22de+Zwart%2C+Jacco+A%2E%22">de Zwart, Jacco A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lee%2C+Jongho%22">Lee, Jongho</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Sati%2C+Pascal%22">Sati, Pascal</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Reich%2C+Daniel+S%2E%22">Reich, Daniel S.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Duyn%2C+Jeff+H%2E%22">Duyn, Jeff H.</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Jan2012, Vol. 67 Issue 1, p110-117. 8p. – Name: Abstract Label: Abstract Group: Ab Data: Visualizing myelin in human brain may help the study of diseases such as multiple sclerosis. Previous studies based on T1 and T2 relaxation contrast have suggested the presence of a distinct water pool that may report directly on local myelin content. Recent work indicates that T2* contrast may offer particular advantages over T1 and T2 contrast, especially at high field. However, the complex mechanism underlying T2* relaxation may render interpretation difficult. To address this issue, T2* relaxation behavior in human brain was studied at 3 and 7 T. Multiple gradient echoes covering most of the decay curve were analyzed for deviations from mono-exponential behavior. The data confirm the previous finding of a distinct rapidly relaxing signal component ( T2* ∼ 6 ms), tentatively attributed to myelin water. However, in extension to previous findings, this rapidly relaxing component displayed a substantial resonance frequency shift, reaching 36 Hz in the corpus callosum at 7 T. The component's fractional amplitude and frequency shift appeared to depend on both field strength and fiber orientation, consistent with a mechanism originating from magnetic susceptibility effects. The findings suggest that T2* contrast at high field may be uniquely sensitive to tissue myelin content and that proper interpretation will require modeling of susceptibility-induced resonance frequency shifts. Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.22990 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 110 Titles: – TitleFull: Nonexponential T2* decay in white matter. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: van Gelderen, Peter – PersonEntity: Name: NameFull: de Zwart, Jacco A. – PersonEntity: Name: NameFull: Lee, Jongho – PersonEntity: Name: NameFull: Sati, Pascal – PersonEntity: Name: NameFull: Reich, Daniel S. – PersonEntity: Name: NameFull: Duyn, Jeff H. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 67 – Type: issue Value: 1 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
| ResultId | 1 |
