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Delivery Modulation inSilica Mesoporous Supportsvia Alkyl Chain Pore Outlet Decoration.

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Bibliographic Details
Title:	Delivery Modulation inSilica Mesoporous Supportsvia Alkyl Chain Pore Outlet Decoration.
Authors:	Aznar, Elena¹, Sancenón, Félix¹, Marcos, M. Dolores¹, Martínez-Máñez, Ramón¹, Stroeve, Pieter¹, Cano, Joan¹, Amorós, Pedro¹
Source:	Langmuir. Feb2012, Vol. 28 Issue 5, p2986-2996. 11p.
Subjects:	Mesoporous materials, Silica, Transition metal complexes, Controlled release technology, Dyes & dyeing, Organoruthenium compounds, Molecular dynamics, Simulation methods & models
Abstract:	This article focuses on the study of the release ratein a familyof modified silica mesoporous supports. A collection of solids containingethyl, butyl, hexyl, octyl, decyl, octadecyl, docosyl, and triacontylgroups anchored on the pore outlets of mesoporous MCM-41 has beenprepared and characterized. Controlled release from pore voids hasbeen studied through the delivery of the dye complex tris(2,2′-bipyridyl)ruthenium(II).Delivery rates were found to be dependent on the alkyl chain lengthanchored on the pore outlets of the mesoporous scaffolding. Moreover,release rates follow a Higuchi diffusion model, and Higuchi constantsfor the different hybrid solids have been calculated. A decrease ofthe Higuchi constants was observed as the alkyl chain used to tunethe release profile is longer, confirming the effect that the differentalkyl chains anchored into the pore mouths exerted on the deliveryof the cargo. Furthermore, to better understand the relation betweenpore outlets decoration and release rate, studies using moleculardynamics simulations employing force-field methods have been carriedout. A good agreement between the calculations and the experimentalobservations was observed. [ABSTRACT FROM AUTHOR]
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Database:	Engineering Source

Description
Abstract:	This article focuses on the study of the release ratein a familyof modified silica mesoporous supports. A collection of solids containingethyl, butyl, hexyl, octyl, decyl, octadecyl, docosyl, and triacontylgroups anchored on the pore outlets of mesoporous MCM-41 has beenprepared and characterized. Controlled release from pore voids hasbeen studied through the delivery of the dye complex tris(2,2′-bipyridyl)ruthenium(II).Delivery rates were found to be dependent on the alkyl chain lengthanchored on the pore outlets of the mesoporous scaffolding. Moreover,release rates follow a Higuchi diffusion model, and Higuchi constantsfor the different hybrid solids have been calculated. A decrease ofthe Higuchi constants was observed as the alkyl chain used to tunethe release profile is longer, confirming the effect that the differentalkyl chains anchored into the pore mouths exerted on the deliveryof the cargo. Furthermore, to better understand the relation betweenpore outlets decoration and release rate, studies using moleculardynamics simulations employing force-field methods have been carriedout. A good agreement between the calculations and the experimentalobservations was observed. [ABSTRACT FROM AUTHOR]
ISSN:	07437463
DOI:	10.1021/la204438j