View in EDS

Comparative analysis of secreted proteins from normal and preeclamptic trophoblastic cells using proteomic approaches

Saved in:
Bibliographic Details
Title: Comparative analysis of secreted proteins from normal and preeclamptic trophoblastic cells using proteomic approaches
Authors: Epiney, M.1, Ribaux, P.1, Arboit, P.2, Irion, O.1, Cohen, M.1 marie.cohen@hcuge.ch
Source: Journal of Proteomics. Mar2012, Vol. 75 Issue 6, p1771-1777. 7p.
Subjects: Trophoblast, Proteomics, Comparative studies, Preeclampsia, Pregnancy, Mass spectrometry, Pathology
Abstract: Abstract: Preeclampsia (PE) is a pathology of pregnancy which represents the main cause of maternal and perinatal morbidity and mortality. Defective placentation is the first event of this pathology. The purpose of this study was to identify the proteins secreted by cytotrophoblastic cells (CTB) using proteomic approach that are associated with PE. Comparison of secreted proteins by mass spectrometry allowed us to identify 21 proteins which were significantly differentially secreted by control and PE CTB. One protein has been detected exclusively in supernatant of control CTB and was identified as factor XIII chain A. To determine if this observation is due to a difference of protein secretion or gene expression, its mRNA was quantified in all CTB. We found that it was significantly decreased in PE CTB compared to control. Collectively, these data suggest that decrease of factor XIII chain A might be associated with development of PE. [Copyright &y& Elsevier]
Copyright of Journal of Proteomics is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 73281398
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Comparative analysis of secreted proteins from normal and preeclamptic trophoblastic cells using proteomic approaches
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Epiney%2C+M%2E%22">Epiney, M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ribaux%2C+P%2E%22">Ribaux, P.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Arboit%2C+P%2E%22">Arboit, P.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Irion%2C+O%2E%22">Irion, O.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Cohen%2C+M%2E%22">Cohen, M.</searchLink><relatesTo>1</relatesTo><i> marie.cohen@hcuge.ch</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Proteomics%22">Journal of Proteomics</searchLink>. Mar2012, Vol. 75 Issue 6, p1771-1777. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Trophoblast%22">Trophoblast</searchLink><br /><searchLink fieldCode="DE" term="%22Proteomics%22">Proteomics</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Preeclampsia%22">Preeclampsia</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnancy%22">Pregnancy</searchLink><br /><searchLink fieldCode="DE" term="%22Mass+spectrometry%22">Mass spectrometry</searchLink><br /><searchLink fieldCode="DE" term="%22Pathology%22">Pathology</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Abstract: Preeclampsia (PE) is a pathology of pregnancy which represents the main cause of maternal and perinatal morbidity and mortality. Defective placentation is the first event of this pathology. The purpose of this study was to identify the proteins secreted by cytotrophoblastic cells (CTB) using proteomic approach that are associated with PE. Comparison of secreted proteins by mass spectrometry allowed us to identify 21 proteins which were significantly differentially secreted by control and PE CTB. One protein has been detected exclusively in supernatant of control CTB and was identified as factor XIII chain A. To determine if this observation is due to a difference of protein secretion or gene expression, its mRNA was quantified in all CTB. We found that it was significantly decreased in PE CTB compared to control. Collectively, these data suggest that decrease of factor XIII chain A might be associated with development of PE. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Proteomics is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=73281398
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.jprot.2011.12.021
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 1771
    Subjects:
      – SubjectFull: Trophoblast
        Type: general
      – SubjectFull: Proteomics
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Preeclampsia
        Type: general
      – SubjectFull: Pregnancy
        Type: general
      – SubjectFull: Mass spectrometry
        Type: general
      – SubjectFull: Pathology
        Type: general
    Titles:
      – TitleFull: Comparative analysis of secreted proteins from normal and preeclamptic trophoblastic cells using proteomic approaches
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Epiney, M.
      – PersonEntity:
          Name:
            NameFull: Ribaux, P.
      – PersonEntity:
          Name:
            NameFull: Arboit, P.
      – PersonEntity:
          Name:
            NameFull: Irion, O.
      – PersonEntity:
          Name:
            NameFull: Cohen, M.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 16
              M: 03
              Text: Mar2012
              Type: published
              Y: 2012
          Identifiers:
            – Type: issn-print
              Value: 18743919
          Numbering:
            – Type: volume
              Value: 75
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Journal of Proteomics
              Type: main
ResultId 1