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Inhibition of proteolytic activity of periodontal pathogens by casein-derived peptides

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Title: Inhibition of proteolytic activity of periodontal pathogens by casein-derived peptides
Authors: Toh, Elena C.Y.1, Dashper, Stuart G.1, Huq, N. Laila1, Attard, Troy J.1, Cross, Keith J.1, Stanton, David P.1, Reynolds, Eric C. e.reynolds@unimelb.edu.au
Source: International Dairy Journal. May2012, Vol. 24 Issue 1, p22-26. 5p.
Subjects: Pathogenic microorganisms, Caseins, Peptides, Porphyromonas gingivalis, Zinc, Proteolytic enzymes, Milk proteins
Abstract: Abstract: The bovine-casein-derived peptide κ-casein (109–137) has been shown to inhibit the major proteases of the periodontal pathogen Porphyromonas gingivalis. The casein peptides αS1-casein (11–23), β-casein (193–209), κ-casein (106–169) and κ-casein (109–137) were analysed for their inhibitory activity against the whole cell proteolytic activity of the three bacterial pathogens highly associated with chronic periodontitis, P. gingivalis, Treponema denticola and Tannerella forsythia. The peptides β-casein (193–209) and κ-casein (106–169) inhibited the major proteolytic activity of all three pathogens, κ-casein (109–137) inhibited P. gingivalis and T. denticola proteolytic activities while αS1-casein (11–23) only inhibited proteolytic activity associated with P. gingivalis. The peptides β-casein (193–209) and κ-casein (106–169) exhibited synergism with Zn2+ in the inhibition of the P. gingivalis Arg- and Lys-specific proteases. [Copyright &y& Elsevier]
Copyright of International Dairy Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 73287216
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Inhibition of proteolytic activity of periodontal pathogens by casein-derived peptides
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  Data: <searchLink fieldCode="AR" term="%22Toh%2C+Elena+C%2EY%2E%22">Toh, Elena C.Y.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Dashper%2C+Stuart+G%2E%22">Dashper, Stuart G.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Huq%2C+N%2E+Laila%22">Huq, N. Laila</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Attard%2C+Troy+J%2E%22">Attard, Troy J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Cross%2C+Keith+J%2E%22">Cross, Keith J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Stanton%2C+David+P%2E%22">Stanton, David P.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Reynolds%2C+Eric+C%2E%22">Reynolds, Eric C.</searchLink><i> e.reynolds@unimelb.edu.au</i>
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  Data: <searchLink fieldCode="JN" term="%22International+Dairy+Journal%22">International Dairy Journal</searchLink>. May2012, Vol. 24 Issue 1, p22-26. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Pathogenic+microorganisms%22">Pathogenic microorganisms</searchLink><br /><searchLink fieldCode="DE" term="%22Caseins%22">Caseins</searchLink><br /><searchLink fieldCode="DE" term="%22Peptides%22">Peptides</searchLink><br /><searchLink fieldCode="DE" term="%22Porphyromonas+gingivalis%22">Porphyromonas gingivalis</searchLink><br /><searchLink fieldCode="DE" term="%22Zinc%22">Zinc</searchLink><br /><searchLink fieldCode="DE" term="%22Proteolytic+enzymes%22">Proteolytic enzymes</searchLink><br /><searchLink fieldCode="DE" term="%22Milk+proteins%22">Milk proteins</searchLink>
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  Label: Abstract
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  Data: Abstract: The bovine-casein-derived peptide κ-casein (109–137) has been shown to inhibit the major proteases of the periodontal pathogen Porphyromonas gingivalis. The casein peptides αS1-casein (11–23), β-casein (193–209), κ-casein (106–169) and κ-casein (109–137) were analysed for their inhibitory activity against the whole cell proteolytic activity of the three bacterial pathogens highly associated with chronic periodontitis, P. gingivalis, Treponema denticola and Tannerella forsythia. The peptides β-casein (193–209) and κ-casein (106–169) inhibited the major proteolytic activity of all three pathogens, κ-casein (109–137) inhibited P. gingivalis and T. denticola proteolytic activities while αS1-casein (11–23) only inhibited proteolytic activity associated with P. gingivalis. The peptides β-casein (193–209) and κ-casein (106–169) exhibited synergism with Zn2+ in the inhibition of the P. gingivalis Arg- and Lys-specific proteases. [Copyright &y& Elsevier]
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  Data: <i>Copyright of International Dairy Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.idairyj.2011.12.009
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      – Code: eng
        Text: English
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        Type: general
      – SubjectFull: Caseins
        Type: general
      – SubjectFull: Peptides
        Type: general
      – SubjectFull: Porphyromonas gingivalis
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      – SubjectFull: Zinc
        Type: general
      – SubjectFull: Proteolytic enzymes
        Type: general
      – SubjectFull: Milk proteins
        Type: general
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      – TitleFull: Inhibition of proteolytic activity of periodontal pathogens by casein-derived peptides
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              Text: May2012
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              Y: 2012
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