Mapping of 3He apparent diffusion coefficient anisotropy at sub-millisecond diffusion times in an elastase-instilled rat model of emphysema.
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| Title: | Mapping of 3He apparent diffusion coefficient anisotropy at sub-millisecond diffusion times in an elastase-instilled rat model of emphysema. |
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| Authors: | Xu, Xiaojun1,2,3, Boudreau, Mathieu1,2, Ouriadov, Alexei1, Santyr, Giles E.1,4,5 |
| Source: | Magnetic Resonance in Medicine. Apr2012, Vol. 67 Issue 4, p1146-1153. 8p. |
| Abstract: | Hyperpolarized 3He gas can provide detailed anatomical maps of the macroscopic airways in the lungs (i.e., ventilation) as well as insight into the lung microstructure through the apparent diffusion coefficient. In particular, the apparent diffusion coefficient of 3He in the lung exhibits anisotropic effects that depend on diffusion time (δ), and it has been shown to be extraordinarily sensitive to enlargement in terminal airways and alveoli associated with emphysema. In this study, the anisotropic nature of the 3He apparent diffusion coefficient is studied in a rat model of emphysema, based on elastase instillation, specifically for δ values less than one millisecond. Longitudinal ( DL) and transverse ( DT) diffusion coefficients were mapped at δ = 360 μs and δ = 800 μs based on a cylinder model of lung structure and correlated with histological measurement of alveolar damage based on mean linear intercept ( Lm). Whole-lung mean DT measured at δ = 360 μs in the elastase-instilled rat lungs (0.14 ± 0.09 cm2/s) demonstrated the most significant increase ( p = 0.00195) compared to the sham-instilled cohort (0.06 ± 0.06 cm2/s) and had a strong linear correlation with Lm (Pearson's correlation coefficient of 0.9). These results suggest that measurement of 3He apparent diffusion coefficient anisotropy, specifically DT, can provide a sensitive indicator of emphysema, particularly at very short diffusion times (δ = 360 μs). Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: Mapping of <superscript>3</superscript>He apparent diffusion coefficient anisotropy at sub-millisecond diffusion times in an elastase-instilled rat model of emphysema. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Xu%2C+Xiaojun%22">Xu, Xiaojun</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Boudreau%2C+Mathieu%22">Boudreau, Mathieu</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Ouriadov%2C+Alexei%22">Ouriadov, Alexei</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Santyr%2C+Giles+E%2E%22">Santyr, Giles E.</searchLink><relatesTo>1,4,5</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Apr2012, Vol. 67 Issue 4, p1146-1153. 8p. – Name: Abstract Label: Abstract Group: Ab Data: Hyperpolarized 3He gas can provide detailed anatomical maps of the macroscopic airways in the lungs (i.e., ventilation) as well as insight into the lung microstructure through the apparent diffusion coefficient. In particular, the apparent diffusion coefficient of 3He in the lung exhibits anisotropic effects that depend on diffusion time (δ), and it has been shown to be extraordinarily sensitive to enlargement in terminal airways and alveoli associated with emphysema. In this study, the anisotropic nature of the 3He apparent diffusion coefficient is studied in a rat model of emphysema, based on elastase instillation, specifically for δ values less than one millisecond. Longitudinal ( DL) and transverse ( DT) diffusion coefficients were mapped at δ = 360 μs and δ = 800 μs based on a cylinder model of lung structure and correlated with histological measurement of alveolar damage based on mean linear intercept ( Lm). Whole-lung mean DT measured at δ = 360 μs in the elastase-instilled rat lungs (0.14 ± 0.09 cm2/s) demonstrated the most significant increase ( p = 0.00195) compared to the sham-instilled cohort (0.06 ± 0.06 cm2/s) and had a strong linear correlation with Lm (Pearson's correlation coefficient of 0.9). These results suggest that measurement of 3He apparent diffusion coefficient anisotropy, specifically DT, can provide a sensitive indicator of emphysema, particularly at very short diffusion times (δ = 360 μs). Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.23098 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 1146 Titles: – TitleFull: Mapping of 3He apparent diffusion coefficient anisotropy at sub-millisecond diffusion times in an elastase-instilled rat model of emphysema. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Xu, Xiaojun – PersonEntity: Name: NameFull: Boudreau, Mathieu – PersonEntity: Name: NameFull: Ouriadov, Alexei – PersonEntity: Name: NameFull: Santyr, Giles E. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 67 – Type: issue Value: 4 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
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