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Repolarization alternans heterogeneity in healthy subjects and acute myocardial infarction patients

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Title: Repolarization alternans heterogeneity in healthy subjects and acute myocardial infarction patients
Authors: Burattini, Laura l.burattini@univpm.it, Bini, Silvia1, Burattini, Roberto1
Source: Medical Engineering & Physics. Apr2012, Vol. 34 Issue 3, p305-312. 8p.
Subjects: Myocardial infarction, Electrocardiography, Heart rate monitoring, Clinical trials, Medical imaging systems, Electric properties of hearts, Patients
Abstract: Abstract: An association between heterogeneity of repolarization alternans (RA) and cardiac electrical instability has been reported. Characterization of RA in health and identification of physiological RA heterogeneity may help discrimination of abnormal RA cases more likely associated to arrhythmic events. Thus, aim of the present study was the identification of a physiological RA region in terms of mean temporal location (MRAD) with respect to the T apex, and mean amplitude (MRAA), by application of our heart-rate adaptive match filter method to clinical ECG recordings from 51 control healthy (CH) subjects and 43 acute myocardial infarction (AMI) patients. Results indicate that RA occurring within the first half of the T wave is dominant in both CH and AMI populations (74.5% and 53.5% of cases, respectively; P <0.05). Definition of physiological RA region in the MRAD vs. MRAA plane (−83ms≤MRAD≤23ms, 0≤MRAA≤30μV) provided 0% and 32.6% abnormal RA cases among the CH subjects and AMI patients, respectively. We conclude that myocardial infarction may associate with an RA occurring early (MRAD<−83ms) or late (MRAD>23ms) along the JT segment, in addition or in alternative to an abnormally high RA amplitude (MRAA>30μV). [Copyright &y& Elsevier]
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Database: Engineering Source
Description
Abstract:Abstract: An association between heterogeneity of repolarization alternans (RA) and cardiac electrical instability has been reported. Characterization of RA in health and identification of physiological RA heterogeneity may help discrimination of abnormal RA cases more likely associated to arrhythmic events. Thus, aim of the present study was the identification of a physiological RA region in terms of mean temporal location (MRAD) with respect to the T apex, and mean amplitude (MRAA), by application of our heart-rate adaptive match filter method to clinical ECG recordings from 51 control healthy (CH) subjects and 43 acute myocardial infarction (AMI) patients. Results indicate that RA occurring within the first half of the T wave is dominant in both CH and AMI populations (74.5% and 53.5% of cases, respectively; P <0.05). Definition of physiological RA region in the MRAD vs. MRAA plane (−83ms≤MRAD≤23ms, 0≤MRAA≤30μV) provided 0% and 32.6% abnormal RA cases among the CH subjects and AMI patients, respectively. We conclude that myocardial infarction may associate with an RA occurring early (MRAD<−83ms) or late (MRAD>23ms) along the JT segment, in addition or in alternative to an abnormally high RA amplitude (MRAA>30μV). [Copyright &y& Elsevier]
ISSN:13504533
DOI:10.1016/j.medengphy.2011.07.019