Polyphenol-loaded polycaprolactone nanofibers for effective growth inhibition of human cancer cells
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| Title: | Polyphenol-loaded polycaprolactone nanofibers for effective growth inhibition of human cancer cells |
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| Authors: | Kim, Young-Jin1, Park, Mi Ran2, Kim, Min Sung1, Kwon, Oh Hyeong2 ohkwon@kumoh.ac.kr |
| Source: | Materials Chemistry & Physics. Apr2012, Vol. 133 Issue 2/3, p674-680. 7p. |
| Subjects: | Nanofibers, Polyphenols, Polycaprolactone, Cancer cell growth, Drug carriers, Cancer chemotherapy, Polyesters, Biodegradation, Polymers |
| Abstract: | Abstract: The use of polymeric nanofibers as drug carriers can be promising in the future for biomedical applications, especially postoperative local chemotherapy. PCL is a biodegradable polyester that has been frequently explored as implantable carriers for drug delivery systems. To develop a drug carrier that enables cancer therapy, plant polyphenol-loaded PCL nanofibers were fabricated by electrospinning. The resulting nanofibers exhibited a fully interconnected pore structure and their average diameter was increased by the addition of plant polyphenol. ATR-FTIR and XRD results clearly revealed the existence of intermolecular interaction between PCL and plant polyphenol in nanofibers. The crystallinity obtained from the DSC data increased with the incorporation of plant polyphenol from 52.0% to 57.8%. The nanofibers showed no burst release and controlled release of EGCG and CA, which implied the homogenous dispersion and perfect inclusion of plant polyphenol within the nanofibers. The released plant polyphenol can generate H2O2, which is the major cause of cytotoxicity of EGCG and CA. Moreover, H2O2 generated by plant polyphenol is mainly involved in apoptosis of gastric cancer cells by activation of caspase-3. [Copyright &y& Elsevier] |
| Copyright of Materials Chemistry & Physics is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 73964399 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Polyphenol-loaded polycaprolactone nanofibers for effective growth inhibition of human cancer cells – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kim%2C+Young-Jin%22">Kim, Young-Jin</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Park%2C+Mi+Ran%22">Park, Mi Ran</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Kim%2C+Min+Sung%22">Kim, Min Sung</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kwon%2C+Oh+Hyeong%22">Kwon, Oh Hyeong</searchLink><relatesTo>2</relatesTo><i> ohkwon@kumoh.ac.kr</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Materials+Chemistry+%26+Physics%22">Materials Chemistry & Physics</searchLink>. Apr2012, Vol. 133 Issue 2/3, p674-680. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Nanofibers%22">Nanofibers</searchLink><br /><searchLink fieldCode="DE" term="%22Polyphenols%22">Polyphenols</searchLink><br /><searchLink fieldCode="DE" term="%22Polycaprolactone%22">Polycaprolactone</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+cell+growth%22">Cancer cell growth</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+carriers%22">Drug carriers</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+chemotherapy%22">Cancer chemotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Polyesters%22">Polyesters</searchLink><br /><searchLink fieldCode="DE" term="%22Biodegradation%22">Biodegradation</searchLink><br /><searchLink fieldCode="DE" term="%22Polymers%22">Polymers</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract: The use of polymeric nanofibers as drug carriers can be promising in the future for biomedical applications, especially postoperative local chemotherapy. PCL is a biodegradable polyester that has been frequently explored as implantable carriers for drug delivery systems. To develop a drug carrier that enables cancer therapy, plant polyphenol-loaded PCL nanofibers were fabricated by electrospinning. The resulting nanofibers exhibited a fully interconnected pore structure and their average diameter was increased by the addition of plant polyphenol. ATR-FTIR and XRD results clearly revealed the existence of intermolecular interaction between PCL and plant polyphenol in nanofibers. The crystallinity obtained from the DSC data increased with the incorporation of plant polyphenol from 52.0% to 57.8%. The nanofibers showed no burst release and controlled release of EGCG and CA, which implied the homogenous dispersion and perfect inclusion of plant polyphenol within the nanofibers. The released plant polyphenol can generate H2O2, which is the major cause of cytotoxicity of EGCG and CA. Moreover, H2O2 generated by plant polyphenol is mainly involved in apoptosis of gastric cancer cells by activation of caspase-3. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Materials Chemistry & Physics is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.matchemphys.2012.01.050 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 674 Subjects: – SubjectFull: Nanofibers Type: general – SubjectFull: Polyphenols Type: general – SubjectFull: Polycaprolactone Type: general – SubjectFull: Cancer cell growth Type: general – SubjectFull: Drug carriers Type: general – SubjectFull: Cancer chemotherapy Type: general – SubjectFull: Polyesters Type: general – SubjectFull: Biodegradation Type: general – SubjectFull: Polymers Type: general Titles: – TitleFull: Polyphenol-loaded polycaprolactone nanofibers for effective growth inhibition of human cancer cells Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kim, Young-Jin – PersonEntity: Name: NameFull: Park, Mi Ran – PersonEntity: Name: NameFull: Kim, Min Sung – PersonEntity: Name: NameFull: Kwon, Oh Hyeong IsPartOfRelationships: – BibEntity: Dates: – D: 16 M: 04 Text: Apr2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 02540584 Numbering: – Type: volume Value: 133 – Type: issue Value: 2/3 Titles: – TitleFull: Materials Chemistry & Physics Type: main |
| ResultId | 1 |
