Nanoscale Clustering ofCarbohydrate Thiols in MixedSelf-Assembled Monolayers on Gold.
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| Title: | Nanoscale Clustering ofCarbohydrate Thiols in MixedSelf-Assembled Monolayers on Gold. |
|---|---|
| Authors: | Tantakitti, Faifan1, Burk-Rafel, Jesse1, Cheng, Fang1, Egnatchik, Robert1, Owen, Tate1, Hoffman, Matt1, Weiss, Dirk N.1, Ratner, Daniel M.1 |
| Source: | Langmuir. May2012, Vol. 28 Issue 17, p6950-6959. 10p. |
| Subjects: | Carbohydrates, Nanochemistry, Molecular self-assembly, Gold, Solution (Chemistry), Ethylene glycol |
| Abstract: | Self-assembled monolayers (SAMs) bearing pendant carbohydratefunctionalityare frequently employed to tailor glycan-specific bioactivity ontogold substrates. The resulting glycoSAMs are valuable for interrogatingglycan-mediated biological interactions via surface analytical techniques,microarrays, and label-free biosensors. GlycoSAM composition can bereadily modified during assembly by using mixed solutions containingthiolated species, including carbohydrates, oligo(ethylene glycol)(OEG), and other inert moieties. This intrinsic tunability of theself-assembled system is frequently used to optimize bioavailabilityand antibiofouling properties of the resulting SAM. However, untilnow, our nanoscale understanding of the behavior of these mixed glycoSAMshas lacked detail. In this study, we examined the time-dependent clusteringof mixed sugar OEG glycoSAMs on ultraflat gold substrates.Composition and surface morphologic changes in the monolayers wereanalyzed by X-ray photoelectron spectroscopy (XPS) and atomic forcemicroscopy (AFM), respectively. We provide evidence that the observedclustering is consistent with a phase separation process in whichsurface-bound glycans self-associate to form dense glycoclusters withinthe monolayer. These observations have significant implications forthe construction of mixed glycoSAMs for use in biosensing and glycomicsapplications. [ABSTRACT FROM AUTHOR] |
| Copyright of Langmuir is the property of American Chemical Society and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 74760291 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Nanoscale Clustering ofCarbohydrate Thiols in MixedSelf-Assembled Monolayers on Gold. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Tantakitti%2C+Faifan%22">Tantakitti, Faifan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Burk-Rafel%2C+Jesse%22">Burk-Rafel, Jesse</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Cheng%2C+Fang%22">Cheng, Fang</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Egnatchik%2C+Robert%22">Egnatchik, Robert</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Owen%2C+Tate%22">Owen, Tate</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hoffman%2C+Matt%22">Hoffman, Matt</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Weiss%2C+Dirk+N%2E%22">Weiss, Dirk N.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ratner%2C+Daniel+M%2E%22">Ratner, Daniel M.</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Langmuir%22">Langmuir</searchLink>. May2012, Vol. 28 Issue 17, p6950-6959. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Carbohydrates%22">Carbohydrates</searchLink><br /><searchLink fieldCode="DE" term="%22Nanochemistry%22">Nanochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+self-assembly%22">Molecular self-assembly</searchLink><br /><searchLink fieldCode="DE" term="%22Gold%22">Gold</searchLink><br /><searchLink fieldCode="DE" term="%22Solution+%28Chemistry%29%22">Solution (Chemistry)</searchLink><br /><searchLink fieldCode="DE" term="%22Ethylene+glycol%22">Ethylene glycol</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Self-assembled monolayers (SAMs) bearing pendant carbohydratefunctionalityare frequently employed to tailor glycan-specific bioactivity ontogold substrates. The resulting glycoSAMs are valuable for interrogatingglycan-mediated biological interactions via surface analytical techniques,microarrays, and label-free biosensors. GlycoSAM composition can bereadily modified during assembly by using mixed solutions containingthiolated species, including carbohydrates, oligo(ethylene glycol)(OEG), and other inert moieties. This intrinsic tunability of theself-assembled system is frequently used to optimize bioavailabilityand antibiofouling properties of the resulting SAM. However, untilnow, our nanoscale understanding of the behavior of these mixed glycoSAMshas lacked detail. In this study, we examined the time-dependent clusteringof mixed sugar OEG glycoSAMs on ultraflat gold substrates.Composition and surface morphologic changes in the monolayers wereanalyzed by X-ray photoelectron spectroscopy (XPS) and atomic forcemicroscopy (AFM), respectively. We provide evidence that the observedclustering is consistent with a phase separation process in whichsurface-bound glycans self-associate to form dense glycoclusters withinthe monolayer. These observations have significant implications forthe construction of mixed glycoSAMs for use in biosensing and glycomicsapplications. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Langmuir is the property of American Chemical Society and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/la300444h Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 6950 Subjects: – SubjectFull: Carbohydrates Type: general – SubjectFull: Nanochemistry Type: general – SubjectFull: Molecular self-assembly Type: general – SubjectFull: Gold Type: general – SubjectFull: Solution (Chemistry) Type: general – SubjectFull: Ethylene glycol Type: general Titles: – TitleFull: Nanoscale Clustering ofCarbohydrate Thiols in MixedSelf-Assembled Monolayers on Gold. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Tantakitti, Faifan – PersonEntity: Name: NameFull: Burk-Rafel, Jesse – PersonEntity: Name: NameFull: Cheng, Fang – PersonEntity: Name: NameFull: Egnatchik, Robert – PersonEntity: Name: NameFull: Owen, Tate – PersonEntity: Name: NameFull: Hoffman, Matt – PersonEntity: Name: NameFull: Weiss, Dirk N. – PersonEntity: Name: NameFull: Ratner, Daniel M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 07437463 Numbering: – Type: volume Value: 28 – Type: issue Value: 17 Titles: – TitleFull: Langmuir Type: main |
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