Bibliographic Details
| Title: |
Mild Pd/Cu-Catalyzed Sila-Sonogashira Coupling of (Hetero)aryl Bromides with (Hetero)arylethynylsilanes under PTC Conditions. |
| Authors: |
Bellina, Fabio1 bellina@dcci.unipi.it, Lessi, Marco1 |
| Source: |
Synthesis. 2012, Vol. 2012 Issue 6, p773-777. 5p. |
| Subjects: |
Copper catalysts, Sonogashira reaction, Coupling reactions (Chemistry), Phase-transfer catalysis, Acetylene, Arylation, Palladium compounds |
| Abstract: |
The palladium/copper cocatalyzed sila-Sonogashira re-action of (hetero)arylethynysilanes with (hetero)aryl bromides in toluene and water at 40 °C under PTC conditions gave the required di(hetero)arylethynes in moderate to high yields. Activated, deactivated and orito-substituted (hetero)aryl bromides are well tolerated. This protocol also allowed the preparation of symmetrical diarylethynes by double arylation of 1,2-bis(trimethylsilyl)ethyne. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
