Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study
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| Title: | Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study |
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| Authors: | Dlouha, D. dadl@ikem.cz, Pitha, J., Lanska, V., Hubacek, J.A. |
| Source: | Clinica Chimica Acta. Aug2012, Vol. 413 Issue 15/16, p1222-1225. 4p. |
| Subjects: | Gene targeting, Human genetic variation, Telomeres, Cardiovascular diseases, Body mass index, Alpha-ketoglutarate dioxygenase, Ethylenediaminetetraacetic acid |
| Abstract: | Abstract: The FTO gene plays an important role in the determination of body weight and BMI and it has been suspected of being associated with all-cause mortality, cardiovascular disease, cancer and end stage renal disease, but the causal mechanism of these effects is still unknown. One of the possibilities is the potential association with telomere length. Telomeres are repetitive DNA-sequences located at the ends of eukaryotic chromosomes'' length of which is reduced in all somatic cells during ageing. Out of the 908 females (3PMFs study), in 783 females both FTO 1st intron tagging polymorphism (G>T, rs17817449) and the relative telomere length were successfully analysed. The relative telomere length was calculated as the ratio of telomere repeats to single-copy gene copies. The frequencies of the FTO genotypes were similar to other populations (GG=18.3%, GT=49.1% and TT=32.6%). We have detected, that the relative telomere length was significantly shorter (P<0.02, P<0.01 after adjustment for age, BMI, waist and subcutaneous fat), in carriers of at least one FTO risky (G) allele (0.85±0.39) in comparison to the carriers of the protective TT genotype (0.93±0.48). We have demonstrated that the FTO variant could be associated with the relative telomere length. Whether this represents a causality of association between the FTO variant and the non-communicable diseases needs to be further analysed. [Copyright &y& Elsevier] |
| Copyright of Clinica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 76159857 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Dlouha%2C+D%2E%22">Dlouha, D.</searchLink><i> dadl@ikem.cz</i><br /><searchLink fieldCode="AR" term="%22Pitha%2C+J%2E%22">Pitha, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Lanska%2C+V%2E%22">Lanska, V.</searchLink><br /><searchLink fieldCode="AR" term="%22Hubacek%2C+J%2EA%2E%22">Hubacek, J.A.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Clinica+Chimica+Acta%22">Clinica Chimica Acta</searchLink>. Aug2012, Vol. 413 Issue 15/16, p1222-1225. 4p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Gene+targeting%22">Gene targeting</searchLink><br /><searchLink fieldCode="DE" term="%22Human+genetic+variation%22">Human genetic variation</searchLink><br /><searchLink fieldCode="DE" term="%22Telomeres%22">Telomeres</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiovascular+diseases%22">Cardiovascular diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Body+mass+index%22">Body mass index</searchLink><br /><searchLink fieldCode="DE" term="%22Alpha-ketoglutarate+dioxygenase%22">Alpha-ketoglutarate dioxygenase</searchLink><br /><searchLink fieldCode="DE" term="%22Ethylenediaminetetraacetic+acid%22">Ethylenediaminetetraacetic acid</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract: The FTO gene plays an important role in the determination of body weight and BMI and it has been suspected of being associated with all-cause mortality, cardiovascular disease, cancer and end stage renal disease, but the causal mechanism of these effects is still unknown. One of the possibilities is the potential association with telomere length. Telomeres are repetitive DNA-sequences located at the ends of eukaryotic chromosomes'' length of which is reduced in all somatic cells during ageing. Out of the 908 females (3PMFs study), in 783 females both FTO 1st intron tagging polymorphism (G>T, rs17817449) and the relative telomere length were successfully analysed. The relative telomere length was calculated as the ratio of telomere repeats to single-copy gene copies. The frequencies of the FTO genotypes were similar to other populations (GG=18.3%, GT=49.1% and TT=32.6%). We have detected, that the relative telomere length was significantly shorter (P<0.02, P<0.01 after adjustment for age, BMI, waist and subcutaneous fat), in carriers of at least one FTO risky (G) allele (0.85±0.39) in comparison to the carriers of the protective TT genotype (0.93±0.48). We have demonstrated that the FTO variant could be associated with the relative telomere length. Whether this represents a causality of association between the FTO variant and the non-communicable diseases needs to be further analysed. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Clinica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.cca.2012.03.025 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 4 StartPage: 1222 Subjects: – SubjectFull: Gene targeting Type: general – SubjectFull: Human genetic variation Type: general – SubjectFull: Telomeres Type: general – SubjectFull: Cardiovascular diseases Type: general – SubjectFull: Body mass index Type: general – SubjectFull: Alpha-ketoglutarate dioxygenase Type: general – SubjectFull: Ethylenediaminetetraacetic acid Type: general Titles: – TitleFull: Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dlouha, D. – PersonEntity: Name: NameFull: Pitha, J. – PersonEntity: Name: NameFull: Lanska, V. – PersonEntity: Name: NameFull: Hubacek, J.A. IsPartOfRelationships: – BibEntity: Dates: – D: 16 M: 08 Text: Aug2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 00098981 Numbering: – Type: volume Value: 413 – Type: issue Value: 15/16 Titles: – TitleFull: Clinica Chimica Acta Type: main |
| ResultId | 1 |
