View in EDS PDF Full Text

DNA double-strand breaks as potential indicators for the biological effects of ionising radiation exposure from cardiac CT and conventional coronary angiography: a randomised, controlled study.

Saved in:
Bibliographic Details
Title: DNA double-strand breaks as potential indicators for the biological effects of ionising radiation exposure from cardiac CT and conventional coronary angiography: a randomised, controlled study.
Authors: Geisel, Dominik1, Zimmermann, Elke1, Rief, Matthias1, Greupner, Johannes1, Laule, Michael2, Knebel, Fabian2, Hamm, Bernd1, Dewey, Marc marc.dewey@charite.de
Source: European Radiology. Aug2012, Vol. 22 Issue 8, p1641-1650. 10p. 1 Color Photograph, 1 Diagram, 1 Chart, 3 Graphs.
Subjects: Cardiographic tomography, Coronary arterial radiography, Coronary disease, Fluorescence microscopy, Lymphocytes
Abstract: Objectives: To prospectively compare induced DNA double-strand breaks by cardiac computed tomography (CT) and conventional coronary angiography (CCA). Methods: 56 patients with suspected coronary artery disease were randomised to undergo either CCA or cardiac CT. DNA double-strand breaks were assessed in fluorescence microscopy of blood lymphocytes as indicators of the biological effects of radiation exposure. Radiation doses were estimated using dose-length product (DLP) and dose-area product (DAP) with conversion factors for CT and CCA, respectively. Results: On average there were 0.12 ± 0.06 induced double-strand breaks per lymphocyte for CT and 0.29 ± 0.18 for diagnostic CCA ( P < 0.001). This relative biological effect of ionising radiation from CCA was 1.9 times higher ( P < 0.001) than the effective dose estimated by conversion factors would have suggested. The correlation between the biological effects and the estimated radiation doses was excellent for CT (r = 0.951, P < 0.001) and moderate to good for CCA (r = 0.862, P < 0.001). One day after radiation, a complete repair of double-strand breaks to background levels was found in both groups. Conclusions: Conversion factors may underestimate the relative biological effects of ionising radiation from CCA. DNA double-strand break assessment may provide a strategy for individualised assessments of radiation. Key Points: • Radiation dose causes concern for both conventional coronary angiography and cardiac CT. • Estimations of the biological effects of ionising radiation may become feasible. • Fewer DNA double-strand breaks are induced by cardiac CT than CCA. • Conversion factors may underestimate the relative effects of ionising radiation from CCA. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 77440860
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: DNA double-strand breaks as potential indicators for the biological effects of ionising radiation exposure from cardiac CT and conventional coronary angiography: a randomised, controlled study.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Geisel%2C+Dominik%22&quot;&gt;Geisel, Dominik&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zimmermann%2C+Elke%22&quot;&gt;Zimmermann, Elke&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rief%2C+Matthias%22&quot;&gt;Rief, Matthias&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Greupner%2C+Johannes%22&quot;&gt;Greupner, Johannes&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Laule%2C+Michael%22&quot;&gt;Laule, Michael&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Knebel%2C+Fabian%22&quot;&gt;Knebel, Fabian&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hamm%2C+Bernd%22&quot;&gt;Hamm, Bernd&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Dewey%2C+Marc%22&quot;&gt;Dewey, Marc&lt;/searchLink&gt;&lt;i&gt; marc.dewey@charite.de&lt;/i&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Radiology%22&quot;&gt;European Radiology&lt;/searchLink&gt;. Aug2012, Vol. 22 Issue 8, p1641-1650. 10p. 1 Color Photograph, 1 Diagram, 1 Chart, 3 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cardiographic+tomography%22&quot;&gt;Cardiographic tomography&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Coronary+arterial+radiography%22&quot;&gt;Coronary arterial radiography&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Coronary+disease%22&quot;&gt;Coronary disease&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Fluorescence+microscopy%22&quot;&gt;Fluorescence microscopy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Lymphocytes%22&quot;&gt;Lymphocytes&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: To prospectively compare induced DNA double-strand breaks by cardiac computed tomography (CT) and conventional coronary angiography (CCA). Methods: 56 patients with suspected coronary artery disease were randomised to undergo either CCA or cardiac CT. DNA double-strand breaks were assessed in fluorescence microscopy of blood lymphocytes as indicators of the biological effects of radiation exposure. Radiation doses were estimated using dose-length product (DLP) and dose-area product (DAP) with conversion factors for CT and CCA, respectively. Results: On average there were 0.12 &#177; 0.06 induced double-strand breaks per lymphocyte for CT and 0.29 &#177; 0.18 for diagnostic CCA ( P &lt; 0.001). This relative biological effect of ionising radiation from CCA was 1.9 times higher ( P &lt; 0.001) than the effective dose estimated by conversion factors would have suggested. The correlation between the biological effects and the estimated radiation doses was excellent for CT (r = 0.951, P &lt; 0.001) and moderate to good for CCA (r = 0.862, P &lt; 0.001). One day after radiation, a complete repair of double-strand breaks to background levels was found in both groups. Conclusions: Conversion factors may underestimate the relative biological effects of ionising radiation from CCA. DNA double-strand break assessment may provide a strategy for individualised assessments of radiation. Key Points: • Radiation dose causes concern for both conventional coronary angiography and cardiac CT. • Estimations of the biological effects of ionising radiation may become feasible. • Fewer DNA double-strand breaks are induced by cardiac CT than CCA. • Conversion factors may underestimate the relative effects of ionising radiation from CCA. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=77440860
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00330-012-2426-1
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 1641
    Subjects:
      – SubjectFull: Cardiographic tomography
        Type: general
      – SubjectFull: Coronary arterial radiography
        Type: general
      – SubjectFull: Coronary disease
        Type: general
      – SubjectFull: Fluorescence microscopy
        Type: general
      – SubjectFull: Lymphocytes
        Type: general
    Titles:
      – TitleFull: DNA double-strand breaks as potential indicators for the biological effects of ionising radiation exposure from cardiac CT and conventional coronary angiography: a randomised, controlled study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Geisel, Dominik
      – PersonEntity:
          Name:
            NameFull: Zimmermann, Elke
      – PersonEntity:
          Name:
            NameFull: Rief, Matthias
      – PersonEntity:
          Name:
            NameFull: Greupner, Johannes
      – PersonEntity:
          Name:
            NameFull: Laule, Michael
      – PersonEntity:
          Name:
            NameFull: Knebel, Fabian
      – PersonEntity:
          Name:
            NameFull: Hamm, Bernd
      – PersonEntity:
          Name:
            NameFull: Dewey, Marc
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2012
              Type: published
              Y: 2012
          Identifiers:
            – Type: issn-print
              Value: 09387994
          Numbering:
            – Type: volume
              Value: 22
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: European Radiology
              Type: main
ResultId 1