DNA double-strand breaks as potential indicators for the biological effects of ionising radiation exposure from cardiac CT and conventional coronary angiography: a randomised, controlled study.
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| Title: | DNA double-strand breaks as potential indicators for the biological effects of ionising radiation exposure from cardiac CT and conventional coronary angiography: a randomised, controlled study. |
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| Authors: | Geisel, Dominik1, Zimmermann, Elke1, Rief, Matthias1, Greupner, Johannes1, Laule, Michael2, Knebel, Fabian2, Hamm, Bernd1, Dewey, Marc marc.dewey@charite.de |
| Source: | European Radiology. Aug2012, Vol. 22 Issue 8, p1641-1650. 10p. 1 Color Photograph, 1 Diagram, 1 Chart, 3 Graphs. |
| Subjects: | Cardiographic tomography, Coronary arterial radiography, Coronary disease, Fluorescence microscopy, Lymphocytes |
| Abstract: | Objectives: To prospectively compare induced DNA double-strand breaks by cardiac computed tomography (CT) and conventional coronary angiography (CCA). Methods: 56 patients with suspected coronary artery disease were randomised to undergo either CCA or cardiac CT. DNA double-strand breaks were assessed in fluorescence microscopy of blood lymphocytes as indicators of the biological effects of radiation exposure. Radiation doses were estimated using dose-length product (DLP) and dose-area product (DAP) with conversion factors for CT and CCA, respectively. Results: On average there were 0.12 ± 0.06 induced double-strand breaks per lymphocyte for CT and 0.29 ± 0.18 for diagnostic CCA ( P < 0.001). This relative biological effect of ionising radiation from CCA was 1.9 times higher ( P < 0.001) than the effective dose estimated by conversion factors would have suggested. The correlation between the biological effects and the estimated radiation doses was excellent for CT (r = 0.951, P < 0.001) and moderate to good for CCA (r = 0.862, P < 0.001). One day after radiation, a complete repair of double-strand breaks to background levels was found in both groups. Conclusions: Conversion factors may underestimate the relative biological effects of ionising radiation from CCA. DNA double-strand break assessment may provide a strategy for individualised assessments of radiation. Key Points: • Radiation dose causes concern for both conventional coronary angiography and cardiac CT. • Estimations of the biological effects of ionising radiation may become feasible. • Fewer DNA double-strand breaks are induced by cardiac CT than CCA. • Conversion factors may underestimate the relative effects of ionising radiation from CCA. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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