Detection of osteoarthritis in knee and hip joints by fast field-cycling NMR.
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| Title: | Detection of osteoarthritis in knee and hip joints by fast field-cycling NMR. |
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| Authors: | Broche, Lionel M.1, Ashcroft, George P.2, Lurie, David J.1 |
| Source: | Magnetic Resonance in Medicine. Aug2012, Vol. 68 Issue 2, p358-362. 5p. |
| Abstract: | It is known that in the early stages of osteoarthritis, the concentration of glycan proteins decreases in articular cartilage. This phenomenon is under active research to develop a means to characterize osteoarthritis accurately in the early stages of the disease, when still reversible. However, no method of quantification has yet shown clear success in this area. In this article, we propose a novel approach to detect glycan depletion using fast field-cycling NMR. This technique was previously reported to allow noninvasive measurement of protein concentration via the 14N quadrupolar relaxation in certain amide groups. We have demonstrated that the articular cartilage exhibits clear quadrupolar peaks that can be measured by a benchtop fast field-cycling NMR device and which changes significantly between normal and diseased tissues ( P < 0.01). This signal is probably glycan specific. The method may have potential for early evaluation of osteoarthritis in patients on fast field-cycling-MRI scanners currently under evaluation in the authors' laboratory. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 77684699 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Detection of osteoarthritis in knee and hip joints by fast field-cycling NMR. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Broche%2C+Lionel+M%2E%22">Broche, Lionel M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ashcroft%2C+George+P%2E%22">Ashcroft, George P.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Lurie%2C+David+J%2E%22">Lurie, David J.</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Aug2012, Vol. 68 Issue 2, p358-362. 5p. – Name: Abstract Label: Abstract Group: Ab Data: It is known that in the early stages of osteoarthritis, the concentration of glycan proteins decreases in articular cartilage. This phenomenon is under active research to develop a means to characterize osteoarthritis accurately in the early stages of the disease, when still reversible. However, no method of quantification has yet shown clear success in this area. In this article, we propose a novel approach to detect glycan depletion using fast field-cycling NMR. This technique was previously reported to allow noninvasive measurement of protein concentration via the 14N quadrupolar relaxation in certain amide groups. We have demonstrated that the articular cartilage exhibits clear quadrupolar peaks that can be measured by a benchtop fast field-cycling NMR device and which changes significantly between normal and diseased tissues ( P < 0.01). This signal is probably glycan specific. The method may have potential for early evaluation of osteoarthritis in patients on fast field-cycling-MRI scanners currently under evaluation in the authors' laboratory. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.23266 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 358 Titles: – TitleFull: Detection of osteoarthritis in knee and hip joints by fast field-cycling NMR. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Broche, Lionel M. – PersonEntity: Name: NameFull: Ashcroft, George P. – PersonEntity: Name: NameFull: Lurie, David J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 68 – Type: issue Value: 2 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
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