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Impact of postimplant edema on V100 and D90 in prostate brachytherapy: can implant quality be predicted on day 0?

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Title: Impact of postimplant edema on V100 and D90 in prostate brachytherapy: can implant quality be predicted on day 0?
Authors: Waterman, Frank M.1 frank.waterman@mail.tju.edu, Dicker, Adam P.1
Source: International Journal of Radiation Oncology, Biology, Physics. Jul2002, Vol. 53 Issue 3, p610. 12p.
Subjects: Prostate cancer, Edema
Abstract: Purpose: To determine the effect of edema on the dosimetric parameters V100 (percentage of prostate volume that received a dose equal to or greater than the prescribed dose) and D90 (minimal dose delivered to 90% of prostate volume) in 125I prostate brachytherapy and to determine whether the edema can be used to predict implant quality on the day of the implant (Day 0).Methods and Materials: Fifty consecutive patients treated with 125I implants who had two postimplant CT scans were selected for this study. The mean interval between the studies was 46 ± 23 days. The implants were preplanned to deliver 150 Gy to the prostate plus a 3–5-mm symmetric dose margin using peripherally loaded 0.4–0.6-mCi (NIST-99) 125I seeds. A dose-volume histogram was compiled for each postimplant CT scan. The V100 and D90 from the first and second CT scans were compared to determine the effect of edema on these parameters. A multivariate regression analysis was performed to define the linear relationships for predicting the V100 or D90 at 30–60 days after implant from the magnitude of the edema and the values of V100 and D90 on Day 0.Results: V100 and D90 increased by 5% ± 6% and 15% ± 17%, respectively, during the interval between the first and second postimplant CT scans. The mean edema was 1.53 ± 0.20. The increases in V100 and D90 were found to be proportional to the edema and the values of V100 and D90 on Day 0. The increase in V100 was also found to depend on the width of the preplan dose margin. Linear relationships were derived that predict the V100 and D90 at 30–60 days after implant with a standard error of ±4% and ±24 Gy, respectively.Conclusion: V100 and D90 increased by 5% ± 6% and 15% ± 17%, respectively, during the first 30–60 days after implant. The results of a multivariate linear regression analysis showed that the increases in V100 and D90 were proportional to both the magnitude of the edema and the values of these parameters on Day 0. The relationships derived by linear regression analysis predict V100 and D90 at 30–60 days after implant to within ±4% and ±24 Gy, respectively. However, predicting the 30–60-day V100 and D90 on Day 0 is a poor substitute for obtaining a 30–60-day CT scan, because the uncertainty in the predicted values is greater by a factor of ≥2. Nevertheless, on average, the predicted values should provide a more reliable estimate of the actual V100 and D90 than the Day 0 values that ignore the effect of edema altogether. The increase in V100 was also found to depend on the width of the preplan dose margin; therefore, our results for V100 are only valid for implants planned with a 3–5-mm margin. [Copyright &y& Elsevier]
Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubTypeId: academicJournal
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  Label: Title
  Group: Ti
  Data: Impact of postimplant edema on V<subscript>100</subscript> and D<subscript>90</subscript> in prostate brachytherapy: can implant quality be predicted on day 0?
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  Data: <searchLink fieldCode="AR" term="%22Waterman%2C+Frank+M%2E%22">Waterman, Frank M.</searchLink><relatesTo>1</relatesTo><i> frank.waterman@mail.tju.edu</i><br /><searchLink fieldCode="AR" term="%22Dicker%2C+Adam+P%2E%22">Dicker, Adam P.</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics%22">International Journal of Radiation Oncology, Biology, Physics</searchLink>. Jul2002, Vol. 53 Issue 3, p610. 12p.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Prostate+cancer%22">Prostate cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Edema%22">Edema</searchLink>
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  Label: Abstract
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  Data: <UNL TYPE="BAR" STYLE="S">Purpose</UNL>: To determine the effect of edema on the dosimetric parameters V100 (percentage of prostate volume that received a dose equal to or greater than the prescribed dose) and D90 (minimal dose delivered to 90% of prostate volume) in 125I prostate brachytherapy and to determine whether the edema can be used to predict implant quality on the day of the implant (Day 0).<UNL TYPE="BAR" STYLE="S">Methods and Materials</UNL>: Fifty consecutive patients treated with 125I implants who had two postimplant CT scans were selected for this study. The mean interval between the studies was 46 ± 23 days. The implants were preplanned to deliver 150 Gy to the prostate plus a 3–5-mm symmetric dose margin using peripherally loaded 0.4–0.6-mCi (NIST-99) 125I seeds. A dose-volume histogram was compiled for each postimplant CT scan. The V100 and D90 from the first and second CT scans were compared to determine the effect of edema on these parameters. A multivariate regression analysis was performed to define the linear relationships for predicting the V100 or D90 at 30–60 days after implant from the magnitude of the edema and the values of V100 and D90 on Day 0.<UNL TYPE="BAR" STYLE="S">Results</UNL>: V100 and D90 increased by 5% ± 6% and 15% ± 17%, respectively, during the interval between the first and second postimplant CT scans. The mean edema was 1.53 ± 0.20. The increases in V100 and D90 were found to be proportional to the edema and the values of V100 and D90 on Day 0. The increase in V100 was also found to depend on the width of the preplan dose margin. Linear relationships were derived that predict the V100 and D90 at 30–60 days after implant with a standard error of ±4% and ±24 Gy, respectively.<UNL TYPE="BAR" STYLE="S">Conclusion</UNL>: V100 and D90 increased by 5% ± 6% and 15% ± 17%, respectively, during the first 30–60 days after implant. The results of a multivariate linear regression analysis showed that the increases in V100 and D90 were proportional to both the magnitude of the edema and the values of these parameters on Day 0. The relationships derived by linear regression analysis predict V100 and D90 at 30–60 days after implant to within ±4% and ±24 Gy, respectively. However, predicting the 30–60-day V100 and D90 on Day 0 is a poor substitute for obtaining a 30–60-day CT scan, because the uncertainty in the predicted values is greater by a factor of ≥2. Nevertheless, on average, the predicted values should provide a more reliable estimate of the actual V100 and D90 than the Day 0 values that ignore the effect of edema altogether. The increase in V100 was also found to depend on the width of the preplan dose margin; therefore, our results for V100 are only valid for implants planned with a 3–5-mm margin. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/S0360-3016(02)02751-7
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      – Code: eng
        Text: English
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        PageCount: 12
        StartPage: 610
    Subjects:
      – SubjectFull: Prostate cancer
        Type: general
      – SubjectFull: Edema
        Type: general
    Titles:
      – TitleFull: Impact of postimplant edema on V100 and D90 in prostate brachytherapy: can implant quality be predicted on day 0?
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            NameFull: Waterman, Frank M.
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              Text: Jul2002
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              Y: 2002
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