A computational approach to memory deficits in schizophrenia
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| Title: | A computational approach to memory deficits in schizophrenia |
|---|---|
| Authors: | Meeter, M. meeter@psy.uva.nl, Murre, J.M.J.1 jaap@murre.com, Talamini, L.M.1 talamini@psy.uva.nl |
| Source: | Neurocomputing. Jun2002, Vol. 44-46, p929. 8p. |
| Subjects: | Memory disorders, Neuropsychology, Schizophrenia |
| Abstract: | Episodic memory impairment is one of the most reliable neuropsychological findings in schizophrenia. It has been suggested that medial temporal lobe abnormalities in schizophrenia underlie this impairment. We suggest that the specific memory deficits in schizophrenia may be caused by abnormal hippocampo-cortical communication via parahippocampal areas. We have used connectionist simulations to investigate this notion. The simulations involve list learning in a model that incorporates characteristics of the hippocampal and parahippocampal region. In this model context is used to store and recall episodic memories. Reduction of the nodes in the parahippocampal module of the model resulted in a schizophrenia-like memory deficit profile. [Copyright &y& Elsevier] |
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| Database: | Engineering Source |
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